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Novel Chiral PNNP-Ru Complexes:Synthesis and Application in Asymmetric Transfer Hydrogenation of Ketones 被引量:3

Novel Chiral PNNP-Ru Complexes:Synthesis and Application in Asymmetric Transfer Hydrogenation of Ketones
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摘要 The efficient catalytic systems generated in situ from RuCl2(PPh3)3 and chiral ligands N,N-bis[2-(di-o-tolylphosphino)-benzyl]cyclohexane-1,2-diamine(2) were employed for asymmetric transfer hydrogenation of aromatic ketones, giving the corresponding optically active alcohols with high activities(up to 99% conversion) and excellent enantioselectivities(up to 96% e.e.) under mild conditions. The chiral ruthenium(Ⅱ) complex (R,R)-3 has been prepared and characterized by NMR and X-ray crystallography. The efficient catalytic systems generated in situ from RuCl2(PPh3)3 and chiral ligands N,N-bis[2-(di-o-tolylphosphino)-benzyl]cyclohexane-1,2-diamine(2) were employed for asymmetric transfer hydrogenation of aromatic ketones, giving the corresponding optically active alcohols with high activities(up to 99% conversion) and excellent enantioselectivities(up to 96% e.e.) under mild conditions. The chiral ruthenium(Ⅱ) complex (R,R)-3 has been prepared and characterized by NMR and X-ray crystallography.
出处 《Chemical Research in Chinese Universities》 SCIE CAS CSCD 2011年第2期170-173,共4页 高等学校化学研究(英文版)
基金 Supported by the National Natural Science Foundation of China(Nos.20423002 20703034) the Natural Science Foundation of Fujian Province of China(No.2008J0235) the Natural Science Foundation of Guangxi Province of China(No. 0991016)
关键词 Chiral PNNP ligand Ru complex Asymmetric transfer hydrogenation Aromatic ketone Chiral PNNP ligand Ru complex Asymmetric transfer hydrogenation Aromatic ketone
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