指长波动性不对称与冠心病的相关性

Relationship between fluctuating asymmetry of digit length and coronary heart disease

目的探讨指长波动性不对称(FA)与宁夏汉族男性冠心病的相关性。方法采用体质测量法,探讨宁夏汉族男性304例(正常对照组152例,冠心病患者152例)指长FA(2FA、3FA、4FA、5FA)及复合FA(CFA)的均值,并比较其均值的差异性。结果宁夏汉族男性正常对照组与冠心病患者组各指长FA均值均呈现2FA>4FA>3FA>5FA的趋势;冠心病患者组各指长FA均值均高于正常对照组,2FA(P≤0.001)、3FA(P<0.05)、4FA(P<0.05)、CFA(P≤0.01)有显著性差异,且2FA差异最显著;冠心病患者组2FA在|L-R|≥0.04组显著增高(P<0.05);冠心病患者组2FA均值与发病年龄呈负相关(P<0.001)。结论 FA尤其是2FA水平可能是冠心病早期筛查的重要参考指标之一。

Objective To study the relationship between the fluctuating asymmetry （FA） of digit length and coronary heart disease. Methods Using anthropometry, digit length of both hands of 304 individuals （controls： 152; coronary heart disease： 152） were measured in men from Ningxia Han nationality. The FA of digit length were calculated respectively and the mean values of them was compared between coronary heart disease patients and controls. Results Our results showed there was a trend as 2FA 〉 4FA 〉 3FA 〉 5FA in both group; The mean values of each FA were higher in patients than those of in controls. There were significant differences in 2FA （ P 〈 0. 001 ） , 3FA （ P 〈 0.05 ） , 4FA （P 〈 0.05）, composite FA （CFA） （P 〈 0. 01 ）, especially in 2FA between patients and controls. There was a significant difference in I L-R I ≥ 0. 04 on distribution of 2FA between two groups （P 〈 0.05 ） ; It showed a negative relation between 2FA and the age at presentation of coronary heart disease （P 〈 0. 001 ）. Conclusion FA, especially 2FA may be one of the important early diagnosis reference marker for coronary heart disease.