期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

MicroRNA-17-92与肿瘤 被引量：5

miR-17-92 in Cancer
下载PDF
导出
摘要 microRNA是一类在生物体中广泛表达的、非编码调节性小分子RNA（约22-24nt）。它们一经问世,即被发现参与多种疾病的发生。miR-17-92及其旁系同源序列就是其中之一,它们已被证实在肺、心脏及免疫系统的正常发育及肿瘤形成中均起到重要作用。本文从miR-17-92及其旁系同源序列在不同肿瘤组织中的表达及其在肿瘤发生中的分子机制,对这一基因簇与肿瘤发生的关系进行综述。 MicroRNAs（miRNAs） are a class of short regulatory non-coding RNAs（22～24 nt） widely expressed in living organisms.Shortly after their discovery,microRNAs are found to participate in the development of a variety of diseases.miR-17-92 and its paralog are one of them,recent studies have revealed their critical roles not only in the development of lung,heart,immune system but also in carcinogenesis.The present article mainly focuses on their different expression patterns and molecular mechanisms to elucidate their contribution to cancer development.
作者 王早早 徐宁志
机构地区 中国医学科学院肿瘤医院肿瘤研究所细胞生物学及分子生物学实验室
出处 《生理科学进展》 CAS CSCD 北大核心 2011年第2期91-94,共4页 Progress in Physiological Sciences
关键词 miR-17-92 肿瘤 癌基因 抑癌基因 miR-17-92 cluster tumor oncogene tumor suppressor gene
分类号 R730.2 [医药卫生—肿瘤]
  • 相关文献

参考文献19

  • 1Herranz H,Cohen SM.MicroRNAs and gene regulatory networks:managing the impact of noise in biological systems.Genes Dev,2010,24:1339-1344.
  • 2Mendell JT.miRiad Roles for the miR-17-92 cluster in development and disease.Cell,2008,133:217-222.
  • 3Ota A,Tagawa H,Karnan S,et al.Identification and characterization of a novel gene,C13orf25,as a target for 13q31-q32 amplification in malignant lymphoma.Cancer Res,2004,64:3087-3095.
  • 4Ventura A,Young AG,Winslow MM,et al.Targeted deletion reveals essential and overlapping functions of the miR-17-92 family of miRNA clusters.Cell,2008,132:875-886.
  • 5O'Donnell KA,Wentzel EA,Zeller KI,et al.c-Myc-regulated microRNAs modulate E2F1 expression.Nature,2005,435:839-843.
  • 6Olive V,Jiang I,He L.A microRNA polycistron as a potential human oncogene.Nature,2005,435:828-833.
  • 7Ivanovska I,Ball AS,Diaz RL,et al.MicroRNAs in the miR-106b family regulate p21/CDKN1A and promote cell cycle progression.Mol Cell Biol,2008,28:2167-2174.
  • 8Petrocca F,Visone R,Onelli MR,et al.E2F1-regulated microRNAs impair TGFbeta-dependent cell-cycle arrest and apoptosis in gastric cancer.Cancer Cell,2008,13:272-286.
  • 9Wong P,Iwasaki M,Somervaille TC,et al.The miR-17-92 microRNA polycistron regulates MLL leukemia stem cell potential by modulating p21 expression.Cancer Res,2010,70:3833-3842.
  • 10Cloonan N,Brown MK,Steproe AL,et al.The miR-17-5p microRNA is a key regulator of the G1/s phase cell cycle transition.Genome Biol,2008,9:R127.

同被引文献86

  • 1盛熙晖,杜立新.MicroRNA及其在人和动物上的研究进展[J].遗传,2007,29(6):651-658. 被引量：20
  • 2陈川（综述）,俞德超（审阅）,滕理送（审阅）.以VEGF/VEGFR为靶点的抗肿瘤药物的研究进展[J].中国肿瘤生物治疗杂志,2007,14(3):291-295. 被引量：25
  • 3Su WL, Kleinhanz RR, Sehadt EE. Characterizing the role of miRNAs within gene regulatory networks using integrative genomics techniques [J]. Mol Syst Biol,2011,7 : 490.
  • 4Dalal SR, Kwon JH. The role of MicroRNA in inflammatory bowel di- sease [ J ]. Gastroenterol Hepatol,2010,6 ( 11 ) :714 - 722.
  • 5O'connell RM, Chaudhuri AA, Rao DS, et al. MicroRNAs enriched in hematopoietic stem cells differentially regulate long - term hematopoietic output[ J]. Proc Natl Acad Sci U S A ,2010,107(32) :14235 - 14240.
  • 6Satoh J, Tabunoki H. Comprehensive analysis of human microRNA target networks [ J ]. Bio Data Min, 2011,4 ( 1 ) : 17.
  • 7Ventura A, Young AG, Winslow MM, et al. Targeted deletion reveals es- sential and overlapping functions of the miR - 17 through 92 family of miRNA clusters [ J ]. Cell,2008,132 (5) : 875 - 886.
  • 8Lu LF, Liston A.-MicroRNA in the immune system, microRNA as an im- mune system[ J]. Immunology,2009,127 (3) :291 - 298.
  • 9Zhou B, Wang S, Mayr C, et al. miR - 150, a microRNA expressed in mature B and T cells, blocks early B cell development when expressed prematurely[ J]. Proc Natl Acad Sci U S A, 2007,104 ( 17 ) : 7080 - 7085.
  • 10Spierings DC, Mcgoldrick D, Hamihon - Easton AM,et al. Ordered pro- gression of stage - specific miRNA profiles in the mouse B2 B - cell lineage [ J]. Blood,2011,117 (20) :5340 - 5349.

引证文献5

二级引证文献10

生理科学进展
2011年 第2期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部