摘要
目的探讨聚氧化乙烯(PEO)对大鼠骨骼肌微循环灌注的影响。方法 Wistar大鼠16只随机分为两组。经腹腔麻醉后,分别经尾静脉泵入生理盐水(对照组)或10 ppm PEO溶液(实验组),泵入速度均为5 ml/h,持续20 min。选择右侧大腿中段短轴切面,分别于给药前及停药后即刻行对比超声造影检查。实验全程连续监测心电图、颈动脉压、中心静脉压。结果实验组在给药后骨骼肌毛细血管容量由(20.78±2.63)dB增加至(22.40±1.94)dB(P=0.023);微血管血流速度由(0.27±0.08)s-1增加至(0.35±0.13)s-1(P=0.010);微血管血流量由(5.65±1.81)dB/s增加至(7.91±3.28)dB/s(P=0.013)。而对照组在给药前后毛细血管容量[(21.68±2.01)dB比(21.19±1.19)dB,P=0.385]、微血管血流速度[(0.29±0.09)s-1比(0.27±0.06)s-1,P=0.275]、微血管血流量[(6.27±1.94)dB/s比(5.71±1.43)dB/s,P=0.184]差异均无统计学意义。两组在给药前后,大鼠的心率、血压、中心静脉压差异均无统计学意义(P>0.05)。结论 PEO可以显著增加微循环灌注的血流速度和血流量,同时轻度开放骨骼肌毛细血管。
Objective To observe the effects of polyethylene oxide(PEO) on microcirculation of normal rat hindlimb skeletal muscle.Methods Sixteen male Wistar rats were anesthetized and equally and randomly divided into PEO group(administered with 10 ppm PEO solution) and control group(administered with equal volume of normal saline).The PEO solution or saline was separately injected through the caudal vein at a constant rate of 5 ml/h for 20 minutes.Using short axis view at right mid thigh region,contrast-enhanced ultrasonography was performed before and after the administration of solution.Electrocardiogram,blood pressure,and central venous pressure were also monitored.Results In the PEO group,after the administration of PEO,microcirculation capillary volume increased from(20.78±2.63) dB to(22.40±1.94) dB(P=0.023),red blood cell velocity from(0.27±0.08) s-1 to(0.35±0.13) s-1(P=0.010),and capillary blood flow from(5.65±1.81) dB/s to(7.91±3.28) dB/s(P=0.013).In the control group,there were no significant changes in microcirculation capillary volume,red blood cell velocity,and capillary blood flow(all P0.05) after the injection of normal saline.The changes of heart rates,blood pressures and central venous pressure were not significant after the administration of either PEO or saline(all P0.05).Conclusion PEO can remarkably increase capillary volume,red blood cell velocity,and capillary blood flow in normal rat hindlimb skeletal muscle.
出处
《中国医学科学院学报》
CAS
CSCD
北大核心
2011年第2期189-193,共5页
Acta Academiae Medicinae Sinicae
关键词
减阻剂
聚氧化乙烯
对比超声造影
微循环
drag-reducing polymers
polyethylene oxide
contrast-enhanced ultrasonography
microcirculation