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广西壮族人Caveolin-3基因多态性与2型糖尿病的关系

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摘要 目的探讨广西壮族人Caveolin-3基因外显子单核苷酸多态性(SNP)与2型糖尿病(T2DM)的关系。方法选择24例T2DM(T2DM组)患者及10例正常对照者(对照组),应用PCR法对两组广西壮族人Caveolin-3基因外显子SNP进行PCR扩增后测序。结果 Caveolin-3基因第2外显子非编码区有2个位点发生突变,分别是12842 A→G和12715 A→T。2位点的等位基因频率在糖尿病组和正常对照组存在统计学差异(P<0.05)。12842A→G和12715 A→T位点有三种联合基因型(AT、GT、GA),其中AT、GA型的分布频率在两组中比较P<0.05。结论 Caveolin-3基因12842 A→G和12715 A→T位点突变可能与T2DM的发病有关。
作者 马静 路文盛 莫书荣 黄媛恒 黄娟娟 杨立会 黄勤
机构地区 广西医科大学 广西壮族自治区人民医院
出处 《山东医药》 CAS 北大核心 2011年第17期36-37,共2页 Shandong Medical Journal
关键词 Caveolin-3基因 外显子 突变 糖尿病 2型
分类号 R587.1 [医药卫生—内分泌] Q78 [生物学—分子生物学]
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参考文献10

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二级参考文献15

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山东医药
2011年 第17期

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