利多卡因联合奥扎格雷钠、低分子肝素钙治疗短暂性脑缺血发作38例疗效观察

Effect Observation that United Ozagrel Lidocaine、Low Molecular Weight Heparin Treatment of Transient Ischemic Attack in 38 Cases

目的:观察利多卡因联合奥扎格雷钠、低分子肝素钙治疗短暂性脑缺血发作(TIA)的临床疗效。方法:将76例TIA患者随机分为两组,治疗组38例,给予利多卡因300mg、奥扎格雷钠80mg分别加入0.9%氯化钠注射液250ml中静滴,qd;低分子肝素钙5 000U脐周皮下注射,1次/12h;辛伐他汀10mg,qd;阿司匹林100mg,qd。对照组给予血栓通10ml加入0.9%氯化钠注射液250ml中静滴,qd;低分子肝素钙5 000U脐周皮下注射,1次/12h;辛伐他汀10mg,qd;阿司匹林100mg,qd。7天为一疗程。疗程结束后,观察临床疗效及血液流变学变化。结果:治疗组痊愈率、总有效率分别为55.2%、76.3%,对照组痊愈率、总有效率分别为26.3%、42.1%,两组相比,痊愈率、总有效率差异有统计学意义(P<0.01),治疗组治疗后的全血高切粘度、全血低切粘度、血浆粘度、血沉及纤维蛋白原均明显下降,凝血酶原时间明显延长,与治疗前相比,差异有统计学意义(P<0.01),血小板聚集率下降治疗组大于对照组(P<0.05);对照组治疗前后上述指标相比,差异无统计学意义(P>0.05)。结论:利多卡因联合奥扎格雷钠、低分子肝素钙是短暂性脑缺血发作(TIA)的安全、有效的治疗方法。

Objective：To observe the clinical effect of lidocaine, sodium ozagral and low-molecular-weight heparins calcium in treatment of transient ischemic attack （TIA）.Metbods：76 patients with TIA were randomly divided into two groups,38 patients of treatment group with TIA was treated with lidocaine300mg, with 0.9% sodium chloride injection 250ml,intravenously, daily, sodium ozagrel 80mg,with 0.9% sodium chloride injection 250ml,intravenously,daily, low-molecular-weight heparins calciumS000U, injecrio hypodermica, twice per day; simvastatin 10rag, orally daily;aspirin 100rag, orally daily.38 patients of the control group with Xueshuantong injection 10ml,with 0.9% sodium chloride injection 250ml,intravenously, daily, low-molecular-weight heparins calcium 5000U, injecrio hypodermica, twice per day; simvastatin 10mg,orally daily;aspirin 100mg, orally daily. Clinical effect and hematological changes were observed after seven day. Results：The total effective rates of the treatment group was 76.3%,with cure rate of 55.2%,respectively for the control group were 42.1% and 26.3%,with a very difference between the two groups （P〈0.01）,After the treatment, whole blood viscosity at a high-shear rate, whole blood viscosity at a low-shear rate, plasma viscosity, erythrocyte sedimentation rate and fibringen were significantly dropped,while prothrombin time was prolong,compared with before, these were significantly difference（P〈0.01）,platelet aggregation was improved after treatment,but treatment group was better than the control （P〈0.05）;For the control group there was no significantly difference than hefore（P〉0.05）.Conclusion： Lidocaine,sodium ozagral and low-molecular-weight heparins calcium was an effective cure for TIA.