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Expression of hippocampal adrenergic receptor mRNA in a rat model of depression

Expression of hippocampal adrenergic receptor mRNA in a rat model of depression
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摘要 Adrenergic receptor dysfunction is suggested as a potential cause of hippocampal vulnerability to stress-related pathology. We examined mRNA expression of adrenergic receptor (AR) subtypes α1-AR, α1-AR, and β1-AR in hippocampal subregions (CA1, CA3, dentate gyrus) using in situ hybridization in a depression model induced by chronic unpredictable mild stress and social isolation, α1-AR mRNA expression was significantly increased in the CA3 and dentate gyrus, β1-AR mRNA was significantly increased in the CA1, and α1-AR mRNA remained unchanged in all regions of depression rats compared with controls. Thus, different AR subtypes exhibit a differing pattern of mRNA expression in various hippocampal subregions following depression. Adrenergic receptor dysfunction is suggested as a potential cause of hippocampal vulnerability to stress-related pathology. We examined mRNA expression of adrenergic receptor (AR) subtypes α1-AR, α1-AR, and β1-AR in hippocampal subregions (CA1, CA3, dentate gyrus) using in situ hybridization in a depression model induced by chronic unpredictable mild stress and social isolation, α1-AR mRNA expression was significantly increased in the CA3 and dentate gyrus, β1-AR mRNA was significantly increased in the CA1, and α1-AR mRNA remained unchanged in all regions of depression rats compared with controls. Thus, different AR subtypes exhibit a differing pattern of mRNA expression in various hippocampal subregions following depression.
出处 《Neural Regeneration Research》 SCIE CAS CSCD 2011年第16期1248-1253,共6页 中国神经再生研究(英文版)
基金 Opening Projects from Laboratory of Acupuncture-Medicine, Nanjing University of Chinese Medicine, No. KJA200505, KJA200803 Doctor Station Foundation of the Ministry of Education, No. 2009323711009 the National Natural Science Foundation of China, No. 30901923
关键词 NORADRENALINE adrenergic receptor DEPRESSION HIPPOCAMPUS CA1 CA3 dentate gyrus noradrenaline adrenergic receptor depression hippocampus CA1 CA3 dentate gyrus
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