摘要
目的探讨脑型脂肪酸结合蛋白(B-FABP)在急性脑梗死(ACI)发病过程中的动态变化及临床意义。方法采用ELISA检测100例ACI患者发病l d内、第7d和第l4d内的血清B-FABP,分析其与梗死部位、大小及神经功能缺损的关系。结果 100例脑梗死患者发病l d内、第7d和第l4d血清B-FABP含量水平均明显高于对照组(P<0.01),其中在急性期(发病1d内)B-FABP敏感性达68%;腔隙性梗死组B-FABP水平明显高于其它三组(P<0.01),全前循环梗死组的B-FABP水平高于后循环梗死组与部分前循环梗死组(P<0.05),后循环梗死组高于部分前循环梗死组(P<0.05);B-FABP水平在小病灶梗死组高于大病灶梗死组、中病灶组(P<0.01),而大病灶梗死组高于中病灶组(P<0.05);B-FABP水平在轻型组高于重型组、中型组(P<0.01);重型组高于中型组(P<0.05)。结论 ACI患者血清中B-FABP水平变化与梗死部位、大小和病情严重程度有关,其高敏感性可作为早期诊断脑梗死的潜在、快速的生物学指标。
Objective To explore clinical significance of brain-type fatty acid binding protein（B-FABP） in early diagnosis of patients with acute cerebral infarction.Methods Serum concentrations of B-FABP were detected by using enzyme-linked immunosorbent assay（ELISA）in 100 patients admitted within 24 hours,7 days and 14 days after cerebral infarction,while the relationships between serum concentrations of B-FABP and size,location and neurologic impairment of cerebral infarction were analyzed.50 healthy subjects were selected as control groups.Results We took venous blood samples of 100 patients admitted within 24 hours,7 days and 14 days after stroke onset.Serum concentrations of B-FABP were higher significantly than those of control groups（P0.01）.The sensitivity of serum B-FABP in patients within 24 hours was 68%.Serum concentrations of B-FABP in patients with LACI was highest among four groups（P0.01）.Serum concentrations of B-FABP in patients with TACI was higher than those of other two groups（P0.05）.Serum concentrations of B-FABP in patients with POCI was higher than that in patients with PACI（P0.05）;Serum concentrations of B-FABP in patients with small infarction volume was higher than those of other two groups（P0.01）;Serum concentrations of B-FABP in patients with large infarction volume was higher than that in patients with median infarction volume（P0.05）;According to NIHSS,serum concentrations of B-FABP in mild group was higher than those of other two groups（P0.01）;Serum concentrations of B-FABP in severe group was higher than that in moderate group（P0.05）;The comparisons among groups mentioned above have statistical significance.Conclusions B-FABP may be related to size and location of infarction lesion and the severity of the neurological deficit early to some extent.Higher serum concentration of B-FABP within 24 hours after ischemic infarction may support the early diagnosis of cerebral infarction.
出处
《卒中与神经疾病》
2011年第4期215-218,共4页
Stroke and Nervous Diseases
基金
苏州市科教兴卫基金SWKQ0922
关键词
脑型脂肪酸结合蛋白
急性脑梗死
ELISA
生物学指标
Brain fatty acid-binding protein（B-FABP） Enzyme-linked immunosorbent assay（ELISA） Acute cerebral infarction（ACI） Biological marker
