口服不同单次剂量米非司酮预防早孕人工流产不全的临床研究

Clinical research of taking different single dose Mifepristone to prevent incomplete abortion

目的:探讨早孕负压吸宫术后口服不同单次剂量米非司酮对预防人工流产不全的作用。方法:对1 367例因早孕要求行负压吸宫术且具有人工流产不全高危因素的妇女分为实验组、对照组。于常规负压吸宫术后当天开始,实验组651例患者口服米非司酮75 mg,1次/d,共服用2 d,对照组716例患者,口服米非司酮25 mg,1次/d,共服用6 d。结果:人工流产术后再次刮宫共7例,其中,实验组3例(0.46%),对照组4例(0.56%),组间差异无统计学意义(P>0.05)。对复刮时刮出物病理检查,均未见残留绒毛组织。结论:米非司酮可预防早孕人工流产不全,不同剂量的预防效果无明显差异,增大单次药物剂量可同时增大胃肠道反应,缩短服药时间可增加患者依从性。

Objective： To discuss the role of taking different single dose Mifepristone to prevent incomplete abortion.Methods： 1 367 cases of high risk of incomplete abortion were randomly divided into two groups.At the day after abortion,651 cases of the experimental group were given Mifepristone 75 mg qd×2 d;716 cases of the control group were given Mifepristone 25 mg qd×6 d.Results： 7 cases were given uterine curettage again,3 cases in experimental group（0.46%）,and 4 cases in control group（0.56%）,there was no significant difference between two groups（P〉0.05）.There was no residual villi organization in pathologic examination of the scrap.Conclusion： Mifepristone can prevent incomplete abortion,the effect of different dose is no significantly different,increasing single drug dose can increase gastrointestinal reaction at the same time,and shortening taking time can increase medication adherence.