上气道咳嗽综合征中医治疗及与红细胞免疫的相关性研究

Treatment of the Upper Airway Cough Syndrome(UACS) with Chinese Medicine and the Correlation Research on Erythrocytic Immune Function

目的观察中药(自拟方)加敷贴法治疗上气道咳嗽综合征(UACS)患儿的临床疗效并探讨红细胞免疫在其发病中的意义。方法将90例上气道咳嗽综合征患儿随机分为中药组30例,中药加敷贴组30例,对照组30例,同时选取健康体检儿童30例为正常组。中药组予单纯中药治疗;中药加敷贴组在中药组基础上,加穴位敷贴治疗;西药组予氯雷他定口服,同时配合色甘酸钠滴鼻。观察三组患儿的临床疗效、红细胞C3b受体花环率(RBC-C3bRR)变化情况。结果中药加敷贴组、中药组临床显效率明显优于西药组,差异有统计学意义(P<0.05或P<0.01)。中药加敷贴组患儿咳嗽、咽部不适及咽后壁分泌物改善方面优于西药组,差异有统计学意义(P<0.01);中药加敷贴组患儿滤泡减少改善时间优于西药组,差异有统计学意义(P<0.05)。治疗前三组C3bRR均低于正常组,差异有统计学意义(P<0.01);治疗后中药组及中药加敷贴组C3bRR与西药组比较,差异有统计学意义(P<0.05或P<0.01)。结论红细胞免疫功能的低下参与了UACS患儿的病理损伤过程。中药加敷贴疗法在改善UACS临床症状、调节红细胞免疫功能方面有较好疗效,从而达到有效控制上气道咳嗽综合征的目的。

Objective To observe the clinical efficacy of herbal medicine（self-prepared formula）and acupoint application method on the upper airway cough syndrome（UACS）and explore the significance of erythrocytic immune function in the disease.Methods 90 cases of UACS were randomized into an herbal medicine group（30 cases）,an herbal medicine plus acupoint application group（30 cases）and a control group（30 cases）.Besides,30 children for physical health examination were selected as a normal group.In herbal medicine group,Chinese herbal medicine was simply applied.In herbal medicine plus acupoint application group,on the basic treatment as herbal medicine group,acupoint application was adopted.In western medicine group,loratadine was taken orally and cromolyn sodium nasal drop was combined.The clinical efficacy and the change in red blood cell C3b receptor rosette（RBC-C3bRR）were observed.Results The total effective rate in herbal medicine group and herbal medicine plus acupoint application group were obviously superior to western medicine group,presenting statistical difference（P0.05 or P0.01）.In herbal medicine plus acupoint application group,the improvements in cough,discomfort in the throat and the secretions from the posterior pharyngeal wall were superior to western medicine,presenting statistical difference（P0.01）.In herbal medicine plus acupoint application group,the time for follicle reducing was superior to western medicine,presenting statistical difference（P0.05）.Before treatment,C3bRR of the three groups was lower than that in normal group,presenting statistical difference（P0.01）.After treatment,C3bRR in herbal medicine group and herbal medicine plus acupoint application group was different statistically than that in western medicine group（P0.05 or P0.01）.Conclusion The erythrocytic immune hypofunction is involved in the pathological injury for the children with UACS.The herbal medicine plus acupoint application achieves a better effect on relieving the clinical symptoms of UACS and adjusting erythrocytic immune function.Eventually,this therapy effectively controls UACS.