泽泻香菇调节血脂和抗氧化作用实验研究

Effects of Blood-lipid Regulation and Antioxidation of Rhizoma Alismatis and Lentinus Edodes

目的 :研究药膳泽泻香菇在调节血脂和抗氧化方面的保健功效。方法 :用药膳泽泻香菇掺和到饲料中饲喂实验性高血脂小鼠 30d ,测定血清总胆固醇 (TC)、甘油三酯 (TG)、高密度脂蛋白胆固醇 (HDL -c)、低密度脂蛋白胆固醇 (LDL -c)等指标 ;再用泽泻香菇掺和到饲料中饲喂实验性衰老小鼠 40d ,测定血清及肝脏的超氧化物歧化酶 (SOD)活力、肝脏的谷胱甘肽过氧化物酶 (GSH -Px)活力、总抗氧化 (T -AOC)能力以及LPO含量。结果 :泽泻香菇可以明显降低小鼠的TC、TG、LDL -c、升高HDL -c,改善小鼠的动脉硬化指数 (AI) ,各项指标和对照组比较均有显著性差异 (P <0 .0 1)。泽泻香菇可明显提高血清和肝脏的SOD活力 ,提高肝脏的GSH -Px活力、T -AOC能力 ,降低肝脏LPO含量 ,各项指标与对照组比较均有显著性差异 (P <0 .0 5 ,P <0 .0 1)。结论 :泽泻香菇具有明显的调节血脂及抗氧化延缓衰老的作用。

OBJECTIVE:To study the healthful effects of the medicated diet containing Rhizoma Alismatis and Lentinus Edodes (RALE) in blood-lipid regulation and antioxidation. METHOD:Food containing RALE was fed for 30 days to mice with high blood-fat. The values of TC, TG, HDL-c and LDL-c in the serum were detected. The same food was fed to aged mice for 40 days. The values of SOD in the serum and liver, GSH-Px and T-AOC and the content of LPO in the liver were tested. RESULTS: RALE could markedly reduce the values of TC, TG and LDL-c, increase the value of HDL-c, and improve AI. There were significant differences in all the data when compared with those of the control ( P <0.01). RALE could significantly improve the values of SOD in the serum and liver, GSH-Px in the liver and T-AOC, and reduce the content of LPO in the liver. All the data were significantly different from those of the control ( P <0.05, P <0.01).CONCLUSION:RALE has distinct effects of adjusting blood-lipid, antioxidizing and delaying aging.