摘要
目的探讨左乙拉西坦治疗儿童癫痫的疗效和安全性。方法对我院96例儿童癫痫患者采用左乙拉西坦单药治疗,进行随访,观察其发作次数及不良反应。结果 96例癫痫患者中,68例患者发作控制,14例患者显效,9例患者无效,5例患者加重,总有效率85.4%;不同类型癫痫有效率的比较,差异无统计学意义(P>0.05)。不同类型癫痫治疗前后发作次数均有明显减少,治疗前后发作次数比较,差异有统计学意义(P<0.05);18例患者治疗后出现副反应(发生率为19%),主要表现为嗜睡、头晕及记忆力下降等,对症治疗或达到维持剂量后自行消失。结论左乙拉西坦单药治疗儿童癫痫具有良好的疗效及安全性。
Objective To study the clinical effect and safety of Levetiracetam treatment on epilepsy. Methods All of 96 children patients with epilepsy were treated by Levetiracetam,then follow-up visited,its effect and severe adverse effects were evaluated. Results All of 96 patients completed this study,68 children seizure-free, 14 children controlled 9 children no effect and 5 child aggravated, the total efficiency was 85.4%. No significant difference of the total efficiency was found between different kinds of epilepsy. However,the difference of attacking times among all kinds of groups were siginificant. 18 children had severe adverse effects, which characterized as drowsiness ,dizziness, memory deterioration and so on.These syndromes were disappeared after treatment or reaching the full dose. Conclusion Levetiracetam has good effect and safety on epilepsy.
出处
《中国现代医生》
2012年第10期66-67,共2页
China Modern Doctor
关键词
左乙拉西坦
癫痫
临床疗效
发作
不良反应
Levetiracetam
Epilepsy
Clinical effects
Attacking
Severe adverse effects