色谱保留时间-结构参数定量关系研究

Studies on Quantitative Chromatographic Retention-Structure Relationships

利用量子化学和分子力学等方法计算了 48个烷基苯类化合物的部分电荷、偶极矩、分子表面积、分子体积等反映分子微观特征的结构参数 ,采用遗传函数算法 (GFA)进行回归 ,建立了拟合度高、物理意义明确、预测能力强的保留时间 -结构参数定量关系方程 ,找出了影响烷基苯类化合物色谱保留时间的主要结构因素。

Using quantum and molecular mechanics methods, 48 structural descriptors of alkylbenzene compounds such as atomic partial charge, dipole moment, molecular area, molecular volume etc. were calculated. GFA regression methods were applied to build a quantitative chromatographic retention\|structure relationships equation .The equation have good fitness and strong predictivity . Principle structural factors that effect chromatographic retention of alkylbenzenes were discussed.