摘要
目的制备司帕沙星眼用pH敏感原位凝胶(SF-ISG),并考察其体外角膜透过性。方法以0.3%卡波姆与14%泊洛沙姆为基质,制备SF-ISG;测定其黏度;以同浓度司帕沙星滴眼液为对照,进行家兔眼滞留性研究,并利用Franz扩散池对其体外角膜透过性进行考察。结果 SF-ISG具有假塑性流体特性,黏度随着pH的增加而迅速增大;与SF滴眼液相比,可显著延长兔眼滞留性,并显著提高对体外角膜的透过量(P<0.05)。结论 SF-ISG具有明显的pH敏感性、眼部滞留性及促进角膜透过性,值得进一步研究。
penetration in vttro Objective To prepare sparfloxacin (SF) pH-sensitive in-situ ophthalmic gel (ISG) and study the corneal Methods 0.3% carbopol and 14% poloxamer was applied as gel base to prepare the SF-ISG. The viscosity of the gel was determined. SF eye-drops at the same concentration served as control. Retention capability and corneal penetration of SF-ISG were studied in vitro. Results The SF-ISG had the property of pseudoplastic fluid and the viscosity increased significantly with the increase of pH value. Compared with the SF eye-drops, the gel could significantly enhance the retention capability and corneal penetration in vitro (P〈 0. 05 ). Conclusion The SF-ISG with promising pH-sensitivity, retention capability and corneal penetration in vitro is valuable to be studied further.
出处
《医药导报》
CAS
北大核心
2012年第6期783-785,共3页
Herald of Medicine
关键词
司帕沙星
凝胶
角膜透过性
体外
Sparfloxacin
Gel
Corneal penetration, in vitro