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司帕沙星眼用pH敏感原位凝胶的制备及体外角膜透过性考察 被引量:5

Preparation of Sparfloxacin pH-Sensitive in-situ Ophthalmic Gel and Its Corneal Penetration in Vitro
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摘要 目的制备司帕沙星眼用pH敏感原位凝胶(SF-ISG),并考察其体外角膜透过性。方法以0.3%卡波姆与14%泊洛沙姆为基质,制备SF-ISG;测定其黏度;以同浓度司帕沙星滴眼液为对照,进行家兔眼滞留性研究,并利用Franz扩散池对其体外角膜透过性进行考察。结果 SF-ISG具有假塑性流体特性,黏度随着pH的增加而迅速增大;与SF滴眼液相比,可显著延长兔眼滞留性,并显著提高对体外角膜的透过量(P<0.05)。结论 SF-ISG具有明显的pH敏感性、眼部滞留性及促进角膜透过性,值得进一步研究。 penetration in vttro Objective To prepare sparfloxacin (SF) pH-sensitive in-situ ophthalmic gel (ISG) and study the corneal Methods 0.3% carbopol and 14% poloxamer was applied as gel base to prepare the SF-ISG. The viscosity of the gel was determined. SF eye-drops at the same concentration served as control. Retention capability and corneal penetration of SF-ISG were studied in vitro. Results The SF-ISG had the property of pseudoplastic fluid and the viscosity increased significantly with the increase of pH value. Compared with the SF eye-drops, the gel could significantly enhance the retention capability and corneal penetration in vitro (P〈 0. 05 ). Conclusion The SF-ISG with promising pH-sensitivity, retention capability and corneal penetration in vitro is valuable to be studied further.
作者 邓翔 何文
出处 《医药导报》 CAS 北大核心 2012年第6期783-785,共3页 Herald of Medicine
关键词 司帕沙星 凝胶 角膜透过性 体外 Sparfloxacin Gel Corneal penetration, in vitro
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  • 1王庆利,彭健.Draize眼刺激性试验的评价[J].中药新药与临床药理,2005,16(4):301-304. 被引量:18
  • 2唐晓霞.阿奇霉素与红霉素治疗急性细菌性呼吸道感染的成本-效果分析[J].医药导报,2005,24(9):840-841. 被引量:2
  • 3房建国,胡凯.阿奇霉素临床应用特性与安全性[J].中国民康医学,2006,18(2):70-71. 被引量:18
  • 4李超英.新型眼科用药给药系统[J].中医外治杂志,2006,15(4):3-4. 被引量:6
  • 5中国药典.二部[S].2010:凡例ⅩⅦ.
  • 6崔福德.药剂学[M] .7版.北京:人民卫生出版社,2011:197-198.
  • 7Koch HR, Kulus SC, RoesslerM, et al. Corneal penetration of fluoroquinolones: Aqueous humor concentrations after topical applieation of levofloxacin 0. 5% and ofloxaein 0.3% eyedrops [J]. J Cataract Refract Surg,2005,31 (7) : 1377 -85.
  • 8Lederer CM Jr, Harold RE. Drop size of commercial glaucoma medications[J]. Am J Ophthalmol, 1986, 101 (6) :691-694.
  • 9Wilson SE, Perry HD. Long-term resolution of chronic dry eye symptoms and signs after topical cyclosporine treatment[J].Ophthalmology, 2007, 114(1):76-79.
  • 10Jain D, Carvalho E, Banthia AK, et al. Development of polyvinyl alcohol- gelatin membranes for antibiotic delivery in the eye[J].Drug Dev Ind Pharm, 201 l, 37(2):167-177. DOI: 10.3109/03639045.2010.502533.

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