期刊文献+

Palliative chemotherapy followed by consolidation radiotherapy in patients with advanced and metastatic non-small cell lung cancer not suitable for radical treatment

姑息性化疗联合巩固放疗在不适合根治性手术的晚期转移性非小细胞肺癌患者中的应用(英文)
下载PDF
导出
摘要 Objective:This is a retrospective study to assess the effectiveness of consolidation radiotherapy (CRT) following palliative chemotherapy in patients with metastatic or locally advanced non-small cell lung cancer (NSCLC) who are not suitable for radical treatment.Methods:This study involved retrospective analysis of a prospective database of Northampton Oncology Centre from January 2005 to December 2010,63 patients with advanced/metastatic NSCLC treated at the oncology centre were enrolled.Patients were either treated with high dose (39/36 Gy /13-12 fractions,group 1) or low dose (20 Gy /5 fractions,group 2) CRT or those were not offered any CRT (group 3).Results:There was no significant difference between the three groups as regard age,sex,performance status,comorbidities or chemotherapy given.However there was a statistically significant difference as regard the stage P=0.009 with more stage IV patients at group II and III compared to group I.The mean survival for the three groups was 27 months,14 months &15 months,respectively.There was a statistically significant improvement of survival in patients treated with high dose palliative CRT compared to the other two groups (P=0.006).In multivariate analysis only the radiotherapy dose remains as the only statistical significant factor affecting the survival with hazard ratio 0.372 and confidence interval (0.147-0.726).Conclusion:Despite the limitation of our retrospective study,it is worth considering CRT approach for patients with advanced and metastatic NSCLC-not suitable for radical treatment-who have not progressed on chemotherapy.
出处 《The Chinese-German Journal of Clinical Oncology》 CAS 2012年第6期327-331,共5页 中德临床肿瘤学杂志(英文版)
关键词 consolidation radiotherapy non-small cell lung cancer radiotherapy dose 非小细胞肺癌 放射治疗 转移性 合并症 患者 化疗 晚期 放疗
  • 引文网络
  • 相关文献

参考文献33

  • 1Sadowska A,Nowe V,Janssens A. Customizing systemic therapy in patients with advanced non-small cell lung cancer[J].Ther AdvMed Oncol,2011.207-218.
  • 2Falk SJ,Girling DJ,White RJ. Immediate versus delayed palliative thoracic radiotherapy in patients with unresectable locally advanced non-small cell lung cancer and minimal thoracic symptoms:randomised controlled trial[J].British Medical Journal,2002,(7362):465.doi:10.1136/bmj.325.7362.465.
  • 3Scottish Intercollegiate Guidelines Network. Management of patients with lung cancer:a national clinical guideline[OL].http://www.sign.ac.uk/pdf/sign80.pdf,2012.
  • 4Schiller JH,Harrington D,Belani CP. Comparison of four chemotherapy regimens for advanced non-small cell lung cancer[J].New England Journal of Medicine,2002.92-98.doi:10.1056/NEJMoa011954.
  • 5Eccles BK,Geldart TR,Laurence VM. Experience of first and subsequent-line systemic therapy in the treatment of non-small cell lung cancer[J].Ther Adv Med Oncol,2011.163-170.
  • 6Hansen HH. Treatment of advanced non-small cell lung cancer should include short courses of radiation,with palliation as the aim[J].British Medical Journal,2002.452-453.
  • 7Fairchild A,Harris K,Barnes E. Palliative thoracic radiotherapy for lung cancer:a systematic review[J].Journal of Clinical Oncology,2008.4001-4011.
  • 8Lutz ST,Chow EL,Hartsell WF. A Review of hypofractionated palliative radiotherapy[J].Cancer,2007.1462-1470.
  • 9Simpson JR,Francis ME,Perez-Tamayo R. Palliative radiotherapy for inoperable carcinoma of the lung:final report of the RTOG multi-institutional trial[J].International Journal of Radiation Oncology,Biology,Physics,1985.751-758.
  • 10Teo P,Tai TH,Choy D. A randomized study on palliative radiation therapy for inoperable non-small cell carcinoma of the lung[J].International Journal of Radiation Oncology,Biology,Physics,1988.867-871.

相关主题

;
使用帮助 返回顶部