基于β-环糊精的分子印迹技术识别机理及评价手段

The recognition mechanism and evaluation method of molecular imprinting technique based on β-cyclodextrins

β-环糊精是一种应用较为广泛的生物相容性强的超分子化合物,将环糊精与分子印迹技术相结合,有助于人工合成所需要的智能型主体分子,能够有效地推动分子印迹技术的发展。首先介绍了基于β-环糊精的分子印迹技术的基本原理,并对其识别机制分别从交联剂的选择、模板分子大小以及溶剂的选择3个方面进行阐述;然后分别从电化学法、光谱法、色谱法以及静态吸附法4个方面对MI-β-CDs的选择性进行评价简介;最后对该领域的发展前景进行了展望。

β-cyclodextrin （β-CD） was a widely used high biocompatibility supramolecular compounds. If human control binding sites of β-CD molecular imprinting technology. The could increase the guest molecules＇ combi- ning efficiency and choice and contribute to the synthesis of intelligent host molecules. β-CD was a industrialized products with low costs, and its cavity dimensions was moderate, so it has been used in solid phase extraction, analysis, molecular recognition of chiral separation, chromatography and sensor materials and so on. Molecular imprinting technique based on β-CD combine supramolecular chemistry, macromolecular chemistry and analyti- cal chemistry together to promote the development of molecular imprinting technology. Here, the will review the recent development of molecular imprinting technology based on β-CD. The first part described the funda- mentals of molecular imprinting technology based on β-C.D and respectively from cross-linking agent, template molecular size and solvent to expound its recognition mechanism. The second part introduced the selective evaluation of MI-β-CDs from electrochemical method, and spectrum method, and color spectrum method and static adsorption method. At last, the prospects in this field were pointed out.