Synthesis of Polysubstituted 1,4-Dihydropyridines via Four-component Reactions of Arylamine,Acetylenedicarboxylate, Aromatic Aldehyde and Ethyl Acetoacetate

Synthesis of Polysubstituted 1,4-Dihydropyridines via Four-component Reactions of Arylamine,Acetylenedicarboxylate,Aromatic Aldehyde and Ethyl Acetoacetate

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摘要 An efficient synthetic protocol for the 1,4-diaryl-1,4-dihydropyridines was developed via the domino four-component reaction of arylamine,acetylenedicarboxylate,aromatic aldehyde and ethyl acetoacetate.The reaction mechanism involves the formation of β-enamino ester and its sequential Michael addition to arylidene acetoacetate. An efficient synthetic protocol for the 1,4-diaryl-1,4-dihydropyridines was developed via the domino four-component reaction of arylamine,acetylenedicarboxylate,aromatic aldehyde and ethyl acetoacetate.The reaction mechanism involves the formation of β-enamino ester and its sequential Michael addition to arylidene acetoacetate.

作者 WU Ping XIA Er-yan SUN Jing YAN Chao-guo

机构地区 Department of Biochemical Engineering College of Chemistry&Chemical Engineering

出处《Chemical Research in Chinese Universities》 SCIE CAS CSCD 2012年第4期652-655,共4页 高等学校化学研究（英文版）

基金 Supported by the National Natural Science Foundation of China(No.20972132) the Fund of Key Laboratory of Environmental Resource and Material,Jiangsu Province,China

关键词 1 4-Dihydropyridine β-Enamino ester Domino reaction Four-component reaction 1 4-Dihydropyridine β-Enamino ester Domino reaction Four-component reaction

分类号 O625.631 [理学—有机化学] TQ655 [化学工程—精细化工]

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2012年第4期

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Synthesis of Polysubstituted 1,4-Dihydropyridines via Four-component Reactions of Arylamine,Acetylenedicarboxylate, Aromatic Aldehyde and Ethyl Acetoacetate

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