子宫颈酸性磷酸酶在子宫颈癌早期诊断中的应用

The application of cervical acid phosphatase in the early diagnosis of cervical cancer

目的:探讨子宫颈酸性磷酸酶(cervical acid phosphatase,CAP)在子宫颈癌早期诊断中的意义。方法:用Mark-PAP试剂盒免疫组织化学染色法检测CAP蛋白在350例行常规妇科体检子宫颈组织细胞中的表达,细胞内出现红色沉淀即为CAP阳性,并与液基薄层细胞检测(TCT)确诊结果进行比较。结果:CAP在子宫颈癌患者组织细胞中阳性表达,而正常的子宫颈上皮细胞及炎症细胞中无CAP表达,CAP检测结果与TCT检测确诊结果一致。结论:CAP在子宫颈癌早期诊断中可能具有指导意义。

Objective：To explore the significance of cervical acid phosphatase （CAP） in the early diagnosis of cervical cancer.Methods：The CAP expression of cervical smears of 350 cases was detected by immunohistochemical staining method with Mark-PAP kit. The red granular deposit in cytoplasm was regarded as CAP positive, which was compared with the results diagnosed by Thinprep cytologic test（TCT）. Results：The CAP expression of the cervical smears of the patents with cervical cancer was confirmed,while CAP was negative in normal and inflammatory cervical cells. The results of the CAP test and TCT test were consistent. Conclusions ：The CAP expression may be instructive significance in the early diagnosis of cervical cancer.