RF、GPI、抗CCP抗体联合对类风湿关节炎的检验价值

RF, GPI, anti CCP Antibody Joint of Rheumatoid Arthritis Test Value

目的观察探讨RF、GPI、抗CCP抗体联合在类风湿关节炎（RA）中的检验方法，总结其临床应用价值。方法选取我院2009年6月～2011年6月72例类风湿关节炎的患者，设为观察组，再选取同期体检为健康的人群70例，设为对照组，均进行RF、GPI、抗CCP抗体联合检测，观察比较两组检测结果。结果观察组的RF、GPI、抗CCP抗体检测阳性率明显高于对照组（P〈0．05），具有统计学意义：在特异性方面．以抗CCP抗体最高，联合检测最低，比较差异显著（P〈0．05）；在敏感度方面，以联合检测最高，RF最低，比较差异显著（P〈0．05），具有统计学意义。结论抗CCP抗体可作为检验RA的特异性指标，联合检测可以明显提高RA诊断灵敏度．减少误漏诊发生．

Objective To explore RF, GPI, anti CCP antibody in rheumatoid arthritis （RA） in the inspection method, summarize its clinical application value. Methods From June June to 2011 2009 in our hospital 72 cases of rheumatoid arthritis patients, as the observation group, and then select the same physical examination for the health of the population of 70 patients, as control group, were assessed with RF, GPI, anti CCP antibody detection, the two groups were observed and compared test results. Results In the observation group, RF, GPI, anti CCP antibody positive rate was significantly higher than that in control group （/~〈0.05）, with statistical significance; in the specificity of antibodies to CCP, highest, lowest joint detection, with significant difference （P〈0.05）; in the sensitivity of detection, to the highest the lowest RF, with significant difference （P〈0.05）, with statistical significance. Conclusion Anti CCP antibody can be used as a test for the specificity of RA index, joint detection can significantly improve RA diagnostic sensitivity, reduce misdiagnosis occurred.