摘要
以苯硼酸和2-氟-4-溴碘苯为起始原料,经Suzuki偶联反应合成了色谱纯度99.5%以上的医药和液晶中间体4-溴-2-氟-联苯,目标化合物进行了1HNMR、IR和GC-MS表征。结果表明,反应体系中氧气的存在是导致硼酸自偶副产物产生的主要原因;Pd(PPh3)4催化剂及过量的苯硼酸均会导致三联苯副产物的产生。
The medicine and liquid crystal intermediate 4-bromo-2-fluorobiphenyl of a purity of 99.5 % was synthesized via Suzuki coupling reaction with phenyl boric acid and 2-fluoro-4-bromo-iodobenzene as starting materials. The target compound was characterized by means of 1HNMR, IR and GC - MS. The results of condition experiments show that the existence of oxygen in the reaction system was the major generation reason of the by-product of boric acid self-coupling; the catalyst Pd （ PPh3 ） 4 and the excessive dosage of phenyl boric acid both resulted in the generation of the by-product terphenyl.
出处
《精细化工》
EI
CAS
CSCD
北大核心
2012年第11期1142-1144,共3页
Fine Chemicals
