p-STAT3及其靶基因CyclinD1在尖锐湿疣组织中的表达

Expression of p-STAT3 and CyclinD1 in Condyloma Acuminatum

目的探讨磷酸化STAT3(p-STAT3)和细胞周期素D1(CyclinD1)在尖锐湿疣(CA)组织中的表达及意义。方法采用免疫组化SP法检测30例CA组织中p-STAT3和CyclinD1的表达,并与20例正常包皮组织作对照。结果 CA组织中p-STAT3和CyclinD1的阳性表达率分别为63.33%(19/30)和73.33%(22/30);正常对照组分别为0(0/20)和10.00%(2/20)。CA组织中p-STAT3和CyclinD1的阳性表达率与正常对照组比较差异均具有统计学意义(P均<0.01)。CA组织中p-STAT3和CyclinD1的表达呈正相关(P<0.01)。结论 p-STAT3和CyclinD1在CA组织中异常表达可能导致了CA细胞的过度增殖。

Objective To explore the expression and significance of p-STAT3 and CyclinD1 in Condyloma Acuminatum （CA） tissues. Methods The expression of p-STAT3 and CyclinD1 in specimens from 30 cases of CA and 20 normal foreskin tissues were detected by immunohistochemistry technique. Results The positive rates of p-STAT3 and CyclinD1 were 63.33% （19/30） and 73.33% （22/30） in CA tissues respectively; 0 （0/20） and 10.00% （2/20）in normal controls. The positive rates of p-STAT3 and CyclinD1 were both significantly higher in CA than those in normal controls respectively（ both P 〈 0.01 ）. The expression of p-STAT3 was pos- itively correlated with that of CyclinD1 in CA （ P 〈 0.01 ）. Conclusion There are an abnormal expression of p-STAT3 and CyelinD1 in CA tissues which might induce the over-proliferation of CA cells.