摘要
Background Myocardial damage often occurs after burns. Previously, cardiac enzyme profile was often measured to determine myocardial injury, but was hardly specific. In this study, we investigated early changes of plasma N-terminal pro-brain natriuretic peptide （NT-proBNP） over time and its diagnostic value in burned patients. Methods 39 patients with heat burned were assigned to heart failure group （n = 9）, control group （n = 30）. Plasma NT-ProBNP and troponin Ⅰ（cTnT） were measured at 1st, 3rd, 5th days and 7th day, and patients were subdivided into 2 groups according to their cardiac function. Results Nine patients had heart failure （27.7%） and their NT-proBNP was 1676.03 ± 2190.41 pg/L. Significant difference was found between the heart failure group and control group （P 〈 0.01 ）. Conclusion NT-proBNP is related to the severity of burning and can well reflect the status of myocardial injury in patients with severe burn, and can be used as an ideal marker for myocardial injury in burned patients.
Background Myocardial damage often occurs after burns. Previously, cardiac enzyme profile was often measured to determine myocardial injury, but was hardly specific. In this study, we investigated early changes of plasma N-terminal pro-brain natriuretic peptide （NT-proBNP） over time and its diagnostic value in burned patients. Methods 39 patients with heat burned were assigned to heart failure group （n = 9）, control group （n = 30）. Plasma NT-ProBNP and troponin Ⅰ（cTnT） were measured at 1st, 3rd, 5th days and 7th day, and patients were subdivided into 2 groups according to their cardiac function. Results Nine patients had heart failure （27.7%） and their NT-proBNP was 1676.03 ± 2190.41 pg/L. Significant difference was found between the heart failure group and control group （P 〈 0.01 ）. Conclusion NT-proBNP is related to the severity of burning and can well reflect the status of myocardial injury in patients with severe burn, and can be used as an ideal marker for myocardial injury in burned patients.
基金
supported by Guangdong Province Medical Research Foundation(A2009039)
