乳腺癌患者指长波动性不对称

Fluctuating asymmetry of digit length in breast cancer patients

目的探讨宁夏汉族女性乳腺癌患者指长波动性不对称(FA)。方法采用体质测量法,分析宁夏汉族女性256例(正常对照128例,乳腺癌患者128例)指长FA(2FA、3FA、4FA、5FA)及复合FA(CFA)的均值,比较其均值的差异性,分析指长FA与年龄间的关系。结果宁夏汉族女性正常对照组与乳腺癌患者组各指长FA均值均呈现2FA>4FA>3FA>5FA的趋势;乳腺癌患者组各指长FA均值均高于对照组,2FA(P<0.01)、4FA、5FA、CFA(P<0.05)差异有显著性,且2FA差异最显著;乳腺癌患者组2FA在|L-R|≥0.04组显著增高(P<0.05);乳腺癌患者组2FA均值与发病年龄呈负相关(P<0.001)。结论 FA,尤其是2FA水平可能是宁夏汉族女性乳腺癌早期筛查的重要间接参考指标之一。

Objective To study the fluctuating asymmetry （FA） of digit length in breast cancer patients in women from Ningxia Han nationality. Methods Using anthropometry, digit length of both hands of 256 individuals （ controls： 128; breast cancers ：128 ） were studied. The FA of digit length was calculated and the mean value with compared between breast cancer and control groups. The relationship between the FA of digit length and the age of control and breast cancer groups were also analyzed. Results The results showed the trend of the FA in both group as follows： 2FA 〉4FA 〉 3FA 〉 5FA. The mean values of each FA were higher in breast cancers than those in the controls, and there were significant differences in 2FA（P 〈0. 01）, 4FA（P 〈0. 05） ,5FA（P 〈0. 05）, CFA（P 〈0. 05） between them; There was a significant difference in lL-R1 ≥ 0. 04 on distribution of 2FA between two groups （P 〈 0. 05）. It showed a negative relation between 2FA and the age at presentation of breast cancers （ P 〈 0. 001 ）. Conclusion FA, especially 2FA may be one of the important indirect early diagnosis reference marker for breast cancer.