根治性切除及单纯胆囊切除对Ⅱ期胆囊癌疗效的Meta分析

Meta-analysis of the efficacy of radical-resection and simple-cholecystectomy for gallbladder carcinoma

目的运用Meta分析软件评价胆囊癌根治手术及单纯胆囊切除治疗Ⅱ期胆囊癌的远期疗效。方法通过Pubmed、WOS、万方、维普、中国生物文摘书库检索自1990年1月至2011年12月相关文献,Jadad质量评分评估文献所涉及研究的质量,治疗组为胆囊癌根治术后患者生存人数,对照组为单纯胆囊癌切除术后患者的生存人数,运用Meta分析评估两组患者1、3、5年的生存差异。结果 10篇文献入选病例数共279例,其中根治组146例,单纯切除组133例。Meta分析结果显示:1年生存[OR=3.900,CI=(1.160,13.140),P=0.030],3年生存[OR=2.780,CI=(1.060,7.310),P=0.040],5年生存[OR=3.160,CI=(1.130,8.870),P=0.030],两组差异均有统计学意义。结论同单纯胆囊切除术相比,根治性切除术可提高Ⅱ期胆囊癌术后的1、3、5年生存率。

Objective To evaluate the long-term efficacy of radical resection and simple cholecystectomy for gallbladder cancer by Meta-analysis. Methods Related articls （1990-2011）were searched in Pubmed, WOS, WANGFANG,VIP, CBM. The qualities of the included studies were evaluated by the Jadad scale. 1-,3-, and 5-year overall survival rates were evaluated by Meta-analysis. Results A total of 10 studies were adopted, and the total number of cases was 279. The Meta-analysis showed that ： 1-year OS rate [ OR = 3. 900, C1 = （ 1. 160,13. 140）,P=O. O30J ,there was a significant difference between the two groups;3-year OS rate[ OR =2. 780,CI= （1. 060,7. 310） ,P =0.040] ,difference between the two groups was significant ;5-year OS rate [ OR = 3. 160, CI = （ 1. 130,8. 870 ） , P = 0. 030 ] , significant difference between the two groups was observed. Con- dusions Comparing radical-section with simple-cholecystectomy,radical-section can improve 1-,3- and 5-year OS rates.