乳腺癌患者手术前后血清CA15-3、SA和SIL-2R检测的临床意义

Clinical Significance of Measurement the Changes on Serum CA15-3,SA and SIL-2R Levels Both Before and After Operation in Patients with Breast Cancer

目的:探讨乳腺癌患者手术前后血清CA15-3、SA和SIL-2R水平的变化及临床意义。方法:应用放射免疫分析、分光光度法和酶联法对31例乳腺癌患者进行手术前后血清CA15-3、SA和SIL-2R检测,并与35例正常人作比较。结果:乳腺癌患者在手术前血清CA15-3、SA和SIL-2R水平均非常显著地高于正常人组(P<0.01),手术3个月后则与正常人组比较无显著性差异(P>0.05)。结论:乳腺癌患者血清CA15-3、SA和SIL-2R含量的变化与疾病的发生和发展密切相关。

Objective To explore the clinical relevance of changes on serum CA15-3, SA and SIL-2R levels both before and af- ter operation in patients with breast cancer. Methods Serum CA15-3 （with RIA）, serum SA （with spectrometry） and SIL-2R （with ELISA） levels were determined both before and after operation in 31 patients with breast cancer as well as 35 normal controls. Results Before operation the serum levels of CA15-3, SA and SIL-2R in patients with breast cancer were significantly higher than those of controls（P 〈 0.01 ）. 3 mouths after operation the levels dropped markedly to approaching normal vs controls （P 〉 0.05 ）. Conclusion The serum CA15-3, SA and SIL-2R in patients with breast cancer closely related to the development and progression of the diseases.