308nm准分子光联合他克莫司软膏治疗白癜风临床观察

Cinical observation of the combination therapy of 308 nm excimer laser and tacrolimus on vitiligo

目的观察308nm准分子光联合他克莫司治疗白癜风的临床疗效。方法 360例白癜风患者随机分为联合组和308单频光组,两组均采用准分子光系统进行308nm光疗,联合组同时外用他克莫司软膏。结果联合组和308单频光组的有效率分别为83.9%和70.1%,差异具有统计学意义(P<0.05)。两组临床有效率最高的部位均为颈部、面部和躯干,最低为手足部;稳定期疗效高于进展期,差异均具有统计学意义(P<0.05)。结论 308nm准分子光联合外用他克莫司软膏治疗白癜风临床疗效好。

Objective To observe the clinical effect of the combination therapy of 308nm excimer laser and tacrolimus on vitiligo. Methods Three hundreds and sixty cases with vitiligo were randomly divided into combination therapy group and 308nm excimer laser group. The cases were all treated with 308nm excimer laser, and the combination therapy group was given tacrolimus ointment additionally. Results The total effective rate of combination therapy group was 83.9%, higher than 70.1% of 308nm excimer laser group （P〈0.05）. In the both groups the positions showed the highes total effective rate were neck, face and trunk, and the lowest were hands and feet. The curative effect in stable stage was better than that in progressive stage （P〈0.05）. Conclusion The combination trerapy of tacmlimus ointment and the 308nm excimer laser is superior to 308rim excimer laser monotherapy for the treatment of vitiligo.