摘要
目的考察血清降钙素原(PCT)水平与渗出性胸腔积液病因的关系。方法对渗出性胸腔积液患者进行血清PCT检测。结果纳入70例患者。结核性、肺炎旁性、脓胸、恶性和结缔组织病相关性胸腔积液的平均PCT分别为(0.052±0.006)ng/ml、(0..224±0.223)ng/ml、(3.230±4.517)ng/ml、(0.073±0.031)ng/ml和0.115 ng/ml,各组PCT水平相比有统计学差异(非参数检验,χ2=47.111,P<0.001)。PCT≥0.295 ng/ml为界值时判断脓胸的灵敏度为0.909,特异度为0.949;取PCT≥0.075 ng/ml为界值,对非结核感染性渗出液的灵敏度为0.920,特异度为0.814。结论血PCT水平有助于胸腔渗出液病因的鉴别诊断。
Objective To investigate the relationship between serum procalcitonin（PCT） and the causes of pleural exudates.Methods 70 patients with pleural exudates were given serum PCT assay within 12 hours.Results The average PCT levels of patients with tuberculosis pleurisy,parapneumonic effusion,empyema,malignant effusion and rheumatoid arthritis-associated pleural effusion were（0.052 ±0.006） ng/ml,（0.224 ±0.223） ng/ml,（3.230 ±4.517） ng/ml,（0.073 ±0.031） ng/ml,and 0.115 ng/ml respectively.There were significant differences among the groups（Nonparametric test： χ2 = 47.111,P 0.001）.Patients with empyema were well distinguished from others using cut-off PCT values of ≥0.295 ng / ml（sensitivity： 0.909,specificity： 0.949）.Conclusion Serum level of PCT can separate different causes of pleural exudates.
出处
《临床肺科杂志》
2013年第8期1446-1448,共3页
Journal of Clinical Pulmonary Medicine
基金
合肥市科技攻关项目资助(No 2009-63-58)
关键词
胸腔积液
渗出液
结核性胸膜炎
脓胸
降钙素原
pleural effusion
exudates
empyema
tuberculosis pleurisy
procalcitonin
