期刊文献+

肝动脉化疗栓塞次数对肝癌根治术后复发的影响 被引量:12

Effect of frequency of transcatheter arterial chemoembolization on preventing tumor recurrence after radical resection for hepatocellular carcinoma
下载PDF
导出
摘要 目的:比较不同次数肝动脉化疗栓塞术(TACE)预防原发性肝癌(Hcc)术后复发的作用。方法:回顾性收集2008年1月至2009年6月HCC根治术后接受1次和3次预防性TACE的患者45例,其中接受1次TACE组23例,接受3次TACE组22例,两个组均在术后1~2个月给予首次TACE,此后接受3次TACE组每隔2—4个月重复1次。全部病例在根治术后随访36~40个月,对比分析两组间的累计复发率。结果:HCC根治术后,接受1次TACE组l、2、3年累计复发率分别为30.43%,47.83%,47.83%;接受3次TACE组1、2、3年累计复发率分别为4.55%,27.27%,36.36%。统计学分析结果显示接受3次TACE组的1年内复发率明显低于接受1次TACE组(P=0.022),而2、3年累积复发率两组间差异无统计学意义(P=0.086、P=0.225)。结论:HCC根治术后给予3次预防性TACE能明显降低术后复发高峰期的复发率,延长肝癌患者术后的无瘤生存时间。 Objective: To compare the effect of the frequency of transcatheter arterial chemoembolization (TACE) on preventing tumor recurrence after hepatectomy. Methods: A total of 45 post-operative patients who had received prophylactic TACE once or thrice were retrospectively examined between January 2008 and June 2009. Of the 45 patients, 23 underwent TACE once, and the others un- derwent it thrice. TACE was administered to all patients via the hepatic artery one to two months after operation and was repeated every two to four months with patients who underwent TACE three times. All cases were followed up for 36 to 40 months after surgery. The rates of cumulative recurrence between the two groups were compared. Results: In the group that underwent TACE once, the 1-, 2- and 3-year cumulative recurrence rates were 30.43%, 47.83%, and 47.83%, respectively. In the group that underwent TACE thrice, the 1-, 2- and 3-year cumulative recurrence rates were 4.55%, 27.27%, and 36.36%, respectively. Statistical analysis showed that the relapse rate within one year was lower in the group that underwent TACE thrice than in the group that underwent TACE only once (P-0.022). How- ever, no significant difference in the cumulative recurrence rate was found between the two groups in two and three years (P=0.086, 0.225). Conclusion: Hepatocellular carcinoma patients who undergo preventive TACE three times after hepatectomy exhibit reduced re- currence rates during the peak time of tumor recurrence and extended disease-free survival intervals.
出处 《中国肿瘤临床》 CAS CSCD 北大核心 2013年第16期975-978,共4页 Chinese Journal of Clinical Oncology
基金 国家科技重大专项(编号:2012ZX10002-017) 浙江省重大科技专项(编号:2009C03012-1)资助~~
关键词 化疗栓塞 原发性肝癌 肿瘤复发 根治性切除 chemoembolization, hepatocellular carcinoma, tumor recurrence, curative resection
  • 引文网络
  • 相关文献

参考文献8

二级参考文献41

  • 1Wan-Yee Lau,Eric C.H.Lai,Stephanie H.Y.Lau.The current role of neoadjuvant/adjuvant/chemoprevention therapy in partial hepatectomy for hepatocellular carcinoma:a systematic review[J].Hepatobiliary & Pancreatic Diseases International,2009,8(2):124-133. 被引量:24
  • 2祁付珍,吴健雄.肝癌根治术后肝内复发的相关因素及预防[J].国外医学(肿瘤学分册),2004,31(7):538-541. 被引量:3
  • 3李锦清,张昌卿,张亚奇,陈敏山.肝癌切除术后辅助肝动脉栓塞化疗的价值[J].中国普外基础与临床杂志,2006,13(2):135-137. 被引量:6
  • 4蒋辉,周健,黄勤杰.肝癌切除术后经肝动脉栓塞化疗的临床意义[J].中国血液流变学杂志,2006,16(4):608-610. 被引量:2
  • 5Ikeda Y, Kajiyama K, Adachi E, et al. Early recurrence after surgery of hepatocellular carcinoma. Hepatogastroenterology, 1995,42:469-472.
  • 6Hashimoto T, Nakamura H, Hori S, et al. Hepatocellular carcinoma: efficacy of transcatheter oily chemoembolization in relation to macroscopic and microscopic patterns of tumor growth among 100 patients with partial hepatectomy. Cardiovasc Intervent Radiol, 1995,18:82-86.
  • 7Tung-Ping Poon R, Fan ST, Wong J. Risk factors, prevention, and management of postoperative recurrence after resection of hepatocellular carcinoma. Ann Surg, 2000,232:10-24.
  • 8Huang YH, Wu JC, Lui WY, el al. Prospective case-controlled trial of adjuvant chemotherapy after resection of hepatocellular carcinoma.World J Surg, 2000, 24:551-555.
  • 9Ono T, Yamanoi A, Nazmy El Assal O, et al. Adjuvant chemotherapy after resection of hepatocellular carcinoma causes deterioration of long-term prognosis in cirrhotic patients: metaanalysis of three randomized controlled trials. Cancer. 2001.91:2378-2385.
  • 10Lee JK, Chung YH, Song BC, et al. Recurrences of hepatocellular carcinoma following initial remission by transcatheter arterial chembolization. J Gaslnenterol llepalol 2002.17:52-58.

共引文献214

同被引文献112

引证文献12

二级引证文献82

;
使用帮助 返回顶部