摘要
目的:比较不同次数肝动脉化疗栓塞术(TACE)预防原发性肝癌(Hcc)术后复发的作用。方法:回顾性收集2008年1月至2009年6月HCC根治术后接受1次和3次预防性TACE的患者45例,其中接受1次TACE组23例,接受3次TACE组22例,两个组均在术后1~2个月给予首次TACE,此后接受3次TACE组每隔2—4个月重复1次。全部病例在根治术后随访36~40个月,对比分析两组间的累计复发率。结果:HCC根治术后,接受1次TACE组l、2、3年累计复发率分别为30.43%,47.83%,47.83%;接受3次TACE组1、2、3年累计复发率分别为4.55%,27.27%,36.36%。统计学分析结果显示接受3次TACE组的1年内复发率明显低于接受1次TACE组(P=0.022),而2、3年累积复发率两组间差异无统计学意义(P=0.086、P=0.225)。结论:HCC根治术后给予3次预防性TACE能明显降低术后复发高峰期的复发率,延长肝癌患者术后的无瘤生存时间。
Objective: To compare the effect of the frequency of transcatheter arterial chemoembolization (TACE) on preventing tumor recurrence after hepatectomy. Methods: A total of 45 post-operative patients who had received prophylactic TACE once or thrice were retrospectively examined between January 2008 and June 2009. Of the 45 patients, 23 underwent TACE once, and the others un- derwent it thrice. TACE was administered to all patients via the hepatic artery one to two months after operation and was repeated every two to four months with patients who underwent TACE three times. All cases were followed up for 36 to 40 months after surgery. The rates of cumulative recurrence between the two groups were compared. Results: In the group that underwent TACE once, the 1-, 2- and 3-year cumulative recurrence rates were 30.43%, 47.83%, and 47.83%, respectively. In the group that underwent TACE thrice, the 1-, 2- and 3-year cumulative recurrence rates were 4.55%, 27.27%, and 36.36%, respectively. Statistical analysis showed that the relapse rate within one year was lower in the group that underwent TACE thrice than in the group that underwent TACE only once (P-0.022). How- ever, no significant difference in the cumulative recurrence rate was found between the two groups in two and three years (P=0.086, 0.225). Conclusion: Hepatocellular carcinoma patients who undergo preventive TACE three times after hepatectomy exhibit reduced re- currence rates during the peak time of tumor recurrence and extended disease-free survival intervals.
出处
《中国肿瘤临床》
CAS
CSCD
北大核心
2013年第16期975-978,共4页
Chinese Journal of Clinical Oncology
基金
国家科技重大专项(编号:2012ZX10002-017)
浙江省重大科技专项(编号:2009C03012-1)资助~~
关键词
化疗栓塞
原发性肝癌
肿瘤复发
根治性切除
chemoembolization, hepatocellular carcinoma, tumor recurrence, curative resection