癌胚抗原和血清糖链抗原125联合检测对肺癌诊断的价值及临床意义

The Value and Clinical Significance of joint Detection of Carcinoembryonic Antigen and Serum Carbohydrate Antigen 125 in the Diagnosis of Lung Cancer

目的:对癌胚抗原(CEA)和血清糖链抗原125(CA125)两项指标联合诊断肺癌的价值进行探讨。方法:采用ECLIA法,对肺癌组及正常对照组的血清中癌胚抗原和血清糖链抗原125的含量进行检测。结果:检测发现,肺癌组的两项指标都高于正常对照组(P<0.05)。单一指标检测的特异性较高,但是其灵敏性和准确性却不高。两项指标联合检测则提高了其灵敏性和准确性。结论:癌胚抗原和血清糖链抗原125两项指标联合检测具有互补性,可以提高诊断肺癌的灵敏性和准确性,对肺癌的诊断有一定的临床价值。

Objective：To explore the value of combined detection of carcinoembryonic antigen（CEA） and serum carbohydrate antigen 125（CA125） in the diagnosis of lung cancer.Method：The patients of the lung cancer group and normal control group were given the detection of serum carcinoembryonic antigen and serum carbohydrate antigen 125 through the ECLIA method.Result：The level of the two kinds of tumor markers in the cancer group was higher than that which in the normal control group（P〈0.05）.A single tumor marker showed a relatively high particularity but low sensitivity and accuracy,while the sensitivity and accuracy could be greatly improved by the joint detection.Conclusion：Carcinoembryonic antigen and serum carbohydrate antigen 125 are complementary.The combined detection of them can improve the sensitivity and accuracy of the diagnosis of lung cancer,and have some clinical value in the diagnosis of lung cancer.