抑郁症快感缺失:概念及其神经生物学基础

Anhedonia in Depression:Definition and Neuralbiological Mechanism

快感缺失,兴趣和愉快体验显著减少,是抑郁症的主要症状。然而,至今为止快感缺失的概念、神经生物学基础及其对抑郁症的发生和发展的作用机制并不清楚。本文对抑郁症快感缺失不同成分如期待性快感缺失,消费性快感缺失和决策快感缺失的定义及其相应的大脑奖励系统受损神经机制的研究进展进行回顾,并提出抑郁症快感缺失与奖赏之间的区分和联系对其行为和脑机制的研究非常重要,也有助于对以奖赏损伤为关键症状的精神疾病的诊断和治疗。

Anhedonia, or markedly diminished interest or pleasure, is a hallmark symptom of major depression. So far, anhedonia concept, the neurobiological mechanism and Anhedonia on depression of the occurrence and development of the mechanism of action is not clear. To better understand the role of anhedonia in depression, this paper reviews the defini- tion on three facets of hedonie capacities （anticipatory, consummatory and decisional anhedonia）, and the neural substrates of anhedonia linked to a dysfunction of the dopaminergic reward system. Finally, putting forward the difference and rela- tion of anhedonia and reward on the anhedonia behavior and the brain mechanism research is very important.