CT和UU感染流产孕妇血清TNFα水平的变化

The Change of the Levels of Tumor Necrosis Factor-α in Serum of Abortion Patients Caused by Chlamydia Trachomatis and Ureaplasma Urealyticum Infection

采用聚合酶链反应技术（ＰＣＲ）检测流产孕妇下生殖道分泌物和流产胚胎组织的沙眼衣原体（ＣＴ）和解脲支原体（ＵＵ）ＤＮＡ，用酶标双抗体夹心（ＥＬＩＳＡ）法定量测定流产孕妇血清肿瘤坏死因子 α（ＴＮＦα）。结果提示 ＣＴ、ＵＵ宫内感染的流产孕妇在流产前血清ＴＮＦα水平比正常同孕期孕妇明显升高，也显著高于自身流产后该水平（Ｐ＜０． ００１）。下生殖道ＣＴ，ＵＵ感染的先兆流产患者应用红霉素治疗后血清ＴＮＦα水平明显下降，ＣＴ，ＵＵ阴转，患者保胎成功。结果表明ＣＴ，ＵＵ宫内感染可能是引起孕妇流产前血清ＴＮＦα水平异常升高的重要原因。

An examination was carried out on the TNFα in maternal serum and DNA of chlamydial trachomatis(CT) and ureaplasma urealyticum (UU) in the aborted tissues of abortion group, cervical secretions and control group, by ELISA and PCR respectively. The results showed that there was much higher TNFα level in the serum of women with intrauterine infection of CT and UU before abortion as compared with that of the control group and that of themselves after abortions. There was also much higher TNFα level in the serum of prognostication abortion with CT and UU infection down genital tract before antibiotic treatment as compared with that of the control group and that of themselves after. treatment. The results suggested that the increasment of TNFα level in maternal serum was induced by CT and UU intrauterine infection.