共同装载吴茱萸碱和Fe3O4纳米粒子的磁性药物载体的制备

Preparation of Magnetic Drug Carriers with Evodiamine and Fe_3O_4 Nanoparticles Co-encapsulated

以单甲醚-聚乙二醇-聚(丙交酯-乙交酯)(mPEG-PLGA)作为载体,采用溶液透析的方法共同装载抗癌药物吴茱萸碱和Fe3O4磁性纳米粒子.通过透射电子显微镜、红外光谱、紫外-可见光谱及体外释放实验、普鲁士蓝染色、体外毒性实验和磁靶向研究,综合评价了磁性纳米药物载体的性能.结果表明,磁性药物载体胶束分散性良好,粒径均一,有较高的载药量和包封率,能够实现药物缓释,具有磁靶向特性.

Evodiamine and Fe304 nanoparticles were co-encapsulated by dialysis method with methoxy poly （ ethylene glycol）/poly （lactide-co-glyeolide） （mPEG-PLGA） as carriers. The magnetic drug carriers were characterized through transmission electron microscope （TEM）, Fourier transform infrared spectrum （F＇FIR）, UV-Vis spectrum（UV）, in vitro release action, Prussian blue staining, in vitro cytotoxicity and magnetic tar- geting study. The data suggested that Fe3 04 nanopartieles and drug loaded micelles were spherical morphology with narrow size distribution, and had high entrapment capacity with slow release in vitro release profiles. Furthermore, the Fe304 nanoparticles and drug loaded micelles were safe and had magnetic targeting proper- ties.