摘要
采用整体动物模型观察器官形成期酒精暴露对宫内胚胎发育影响 ,结合酶组织化学和免疫组织化学技术 ,探讨酒精对脑组织中海马区NOS(nirticoxidesynthase活性和nNOS(neuronalnitricoxidesynthase)表达影响。结果显示 1 0g/kg/d组即可出现FAS形态特征 ;酒精能导致脑海马区NOS活性和nNOS表达增强 ,提示NO产量增高。结果说明酒精具有发育毒性 。
Drinking alcohol during pregnancy resulted in a series of developmental abnormalities.To explore its mechanism,this study used the integer animal model to investigate the effects of alcohol on uterus embryonic development in organic orphogenesis.Immunohistochemistery and enzyme histochemistry technique were used to research expression of the activity of nitric oxide synthase and neuronal nitric oxide synthase in hippocampi.The result showed that the dose of 1.0g/kg/d of alcohol could rise to the characteristic of fetal alcohol syndrome.Alcohol could lead to the activity of NOS and nNOS increasing.It is suggested that NO products would be heightened in brain.These results illuminated that alcohol possesses developmental toxicity.The effects of alcohol gave rise to abnormalities of embryonic brain development that may be related to NO increasing.
出处
《中国公共卫生》
CAS
CSCD
北大核心
2000年第12期1099-1100,共2页
Chinese Journal of Public Health
基金
中国博士后基金资助
