胃癌患者血清斯钙素-2基因的表达及临床意义

Clinical significance and expression of stanniocalcin-2 protein detection in serum of gastric cancer patients

目的 探讨斯钙素（STC-2）在胃癌血清中的表达水平及其临床意义.方法 收集2007年7月～2010年7月溧阳市人民医院75例胃癌患者术前术后血清标本及40例胃良性疾病血清标本,ELISA检测STC-2蛋白水平.结果 胃癌患者术前血清STC-2平均水平为（1694.4±566.16）ng/L,同期良性对照血清STC-2蛋白水平为（691.75±318.48）ng/L,差异有统计学意义（P＜ 0.001）.ROC曲线下面积（A UC）为0.945（95％CI：0.908～0.982,P＜ 0.001）.术后7～10 d,胃癌患者血清STC-2水平较术前下降[（1126.0±419.43）ng/L],差异有统计学意义（P＜ 0.001）.结论 胃癌血清STC-2检测可能成为肿瘤早期诊断和预后判断的潜在分子标记.

Objective To explore the expression of stanniocalcin-2 （STC-2） protein in serum of gastric cancer （GC） patients and its clinical significance.Methods STC-2 protein expression was determined by ELISA in serum of 75 GC patients pre-operation and post-operation,and in serum of 40 patients.with benign gastric disease.Samples were collected from July 2007 to July 2010 in People＇s Hospital of Liyang City.Results The level.of serum STC-2 in GC patients pre-operation was （1694.4±566.16） ng/L,which was much higher than that in patients with benign gastric disease （691.75±318.48） ng/L,the differences were statistically significant （P 〈 0.001）,and area under the curve （A UC） was 0.945 （95%CI：0.908-0.982,P 〈 0.001）.The serum STC-2 level was significantly decreased at postoperative 7-10 days （1126.0±419.43） ng/L,compared with preoperative level,the differences were statistically significant （P 〈 0.001）.Conclusion Serum STC-2 level may be a potential biomarker for early diagnosis and prognosis assessment of GC.