摘要
目的 :建立一个比较接近人类条件的急性肝衰竭模型 ,用于人工肝脏治疗的疗效和安全性的测试。方法 :以右旋半乳糖胺来制造猪肝衰竭的大型动物模型 ,分 3组给药 ,剂量分别为0 5、1和 0 75g/kg。观察其临床表现、生理生化指标和病理改变。结果 :3组实验都能引出与人的临床和生化指标变化相近的肝功能衰竭的表现 ,以 0 75g/kg组最为理想。结论 :以 0 75g/kg的半乳糖胺制造的急性肝功能衰竭的猪动物模型 ,符合人工肝脏研究对动物模型的要求。
Aim: To establish a clinically relevant model of fulminant hepatic failure for the test of efficacy and safety of artificial liver support. Methods: We induced a pig model of fulminant hepatic failure by administration of D-galactosamine in the dosage of 0.5 g/kg, 0.75 g/kg and 1 g/kg, and observed the clinical manifestations, biochemical and pathological changes of the diseased pigs. Results: D-galactosamine in the three dosages was able to induce a hepatic failure model, but the dosage of 0.75 g/kg is most suitable for the studies of artificial liver support. Conclusion: A large animal model of fulminant hepatic failure that closely mimics the clinical situation was established. [
出处
《暨南大学学报（自然科学与医学版）》
CAS
CSCD
2000年第6期22-25,共4页
Journal of Jinan University(Natural Science & Medicine Edition)
关键词
肝功能衰竭
猪
动物模型
人工肝脏支持
hepatic failure
\ large animal model
\ artificial liver support
