乳腺癌患者血清PRL及癌细胞PRL-R与预后因素相关性的比较

A Comparative study:The Prognosis Significance of PRL Receptor and Serum In Breast Cancer.

目的 :对乳腺癌患者血清PRL及癌组织PRL R与预后因素的相关性进行比较研究。方法 :采用受体放射配基结合分析法及放射免疫分析法分别测定 94例乳腺癌患者细胞PRL R含量 (≥ 2 0fmol/mg蛋白为受体阳性 )和 75例患者血清PRL含量 (>2 5μg/L为激素阳性 )。统计分析两者与乳腺癌预后因素的相关性。结果 :PRL R阳性率与肿瘤大小、有无腋淋巴结转移、组织学分级、临床分期及增殖细胞核抗原 (PCNA)是否阳性有显著性相关 (P <0 .0 5) ;且PCNA弱阳性者较阴性者 ,淋巴结转移 1～ 3个者较无转移者PRL R阳性率均显著增高 (均P <0 0 5)血清PRL阳性率仅见与组织学级别及临床期别有显著性相关 (P <0 .0 5) ;且与PRL R在临床期别组中的阳性率比较 ,Ⅲ期患者PRL阳性率显著低于PRL R阳性率 ,乳腺癌PRL R与血清PRL阳性率间未见显著性相关 (P >0 .0 5)。结论 :PRL R或血清PRL阳性提示乳腺癌预后不良 ,PRL R估计预后较为灵敏、可靠。

Objective:To compare the prognosis significance of PRL R with serum PRL in primary breast cancer.Methods:The binding sites of PRL R(94 cases) were determined with radioligand binding assay of receptor (≥20 fmol/mg.protein to be regarded as positive).Serum PRL levels(75 cases) were measured by radioimmunoassay (>25 ug/L to be regarded as positive).The relationship between PRL receptor or PRL and clinical prognostic factors of breast cancer were studied.Results:PRL R was correlated to histologic grading,lymph node involvement,clinical staging,tumor size and proliferating cell nuclear antigen (PCNA) level( P <0 05).Furthermore,the incidence of the receptor positive tumor was higher in slight positive PCNA and 1-3 involved lymph nodes than in negative PCNA and O involved lymph nodes. Serum PRL was only correlated to histologic grading and clinical staging( P <0 05),Compared with PRL R positive rate in different clinical stages,PRL positive rate is significantly lower than PRL R( P <0 01)Conclusions:The positive PRL R suggests poor prognosis of breast cancer patient it's a more reliable an sensitive method to evaluate the prognosis of breast cancer.