新一代喹诺酮类盐酸莫西沙星的合成及应用研究进展

Progress in synthesis and applications of moxifloxacin hydrochloride

盐酸莫西沙星是广谱和具有抗菌活性的8-甲氧基氟喹诺酮类抗菌药,综述了近年来其合成方法及用于治疗社区获得性肺炎、慢性支气管炎急性发作、泌尿生殖系感染、急性鼻窦炎等的临床应用情况。结果表明,莫西沙星作为第四代氟喹诺酮类药物无论在药动性、安全性、抗菌活性,还是在抗菌谱和应用方面均是最好的。

Moxifloxacin hydrochloride is a broad-spectrum antimicrobial that belongs to the type of 8-methoxyfluoroquinolone.The synthesis methods of moxifloxacin hydrochloride and its clinical applications,such as the treatment of community-acquired pneumonia,acute exacerbation of chronic bronchitis,urinary and reproductive tract infection,acute sinusitis,are reviewed.As the fourth generation fluoroquinolones,moxifloxacin is the best one whether in its properties of pharmacokinetics,safety,antibacterial activity or the aspects of antibacterial spectrum and application.