贝那普利联合螺内酯治疗扩张型心肌病心力衰竭的临床分析

CLINICAL ANALYSIS OF DILATED CARDIOMYOPATHY WITH HEART FAILURE TREATMENT USING BENAZEPRIL AND SPIRONOLACTONE

目的观察贝那普利和螺内酯治疗扩张型心肌病心力衰竭的有效性。方法将60例扩张型心肌病心力衰竭患者随机分成2组。对照组30例予以地高辛、氢氯噻嗪、倍他乐克等药物治疗,治疗组30例在此基础上加用贝那普利和螺内酯,两组均治疗6个月。结果两组比较,治疗组心功能、左心室射血分数有明显改善,心胸比、BNP下降,治疗组总有效率93%,对照组的总有效率为66%,两组差异有统计学意义(p<0.05)。结论贝那普利联合螺内酯治疗扩张型心肌病心力衰竭疗效显著且安全,并能改善心室重构。

Objective To explore the effectiveness of Benazepril and spironolactone treatment of dilated cardiomyopathy with heart failure. Method 60 patients with dilated cardiomyopathy heart failure were randomly divid- ed into two groups. A control group of 30 patients to be treated with digoxin, hydrochlorothiazide, metoprolol, etc. ; the treatment group of 30 patients on this basis plus benazepril and spironolactone, both groups were treated for 6 months. Result Comparing between two groups, the cardiac function and left ventricular ejection fraction of treatment group obviously improved, cardiothoracic ratio, BNP decreased, total effective rate is 93% ; the total effective rate of control group is 66%, the difference is statistically significant （p 〈0. 05 ）. Conclusion Benazepril combined with spironolactone treatment of dilated eardiomyopathy with heart failure is significant effective and safe and can improve ventricular remodeling.