摘要
目的研究莫诺苷对局灶性脑缺血再灌注(MCAO)大鼠红细胞压积(Hct)的影响。方法改良Longa法制备大鼠MCAO模型,造模后分别给予莫诺苷小剂量(30 mg/kg,n=8)、中剂量(90 mg/kg,n=8)、大剂量(270 mg/kg,n=8)和阿司匹林(n=8)连续灌胃7 d,每天1次。腹主动脉采血,全自动血样测试仪检测Hct。结果模型组大鼠Hct较假手术组显著升高(P<0.001);莫诺苷小、中、大剂量组和阿司匹林组的Hct均比模型组降低(P<0.05)。结论莫诺苷能显著性抑制局灶性脑缺血再灌注引起的Hct升高。
Objective To investigate the effect of morroniside on hematocrit percentage in a rat model of focal cerebral ischemia/reperfu-sion. Methods After the modified model induced with occlusion of middle cerebral artery （MCAO） with suture embolus, morroniside was administered intragastrically at the dose of 30 mg/kg （n=8）, 90 mg/kg （n=8）, and 270 mg/kg （n=8） once a day for 7 d. Acetyl salicylic acid （ASA） was used as positive drug （n=8）. Hematocrit percentage was measured with automatic blood tester. Results Compared with the sham group, hematocrit percentage of the model group significantly increased （P〈0.001）, but increased less in those treated with morroniside and ASA （P〈0.05）. Conclusion Morroniside could inhibit the increase of hematocrit percentage in MCAO rats.
出处
《中国康复理论与实践》
CSCD
北大核心
2014年第3期230-232,共3页
Chinese Journal of Rehabilitation Theory and Practice
基金
"重大新药创制"科技重大专项(No.2009ZX09102201-106)
国家自然科学基金项目(No.30973893
No.81173575
No.30973513)
北京市自然科学基金项目(No.7102077)
北京市教委科技创新平台项目(No.111219)
2011年北京市卫生系统高层次卫生技术人才培养计划项目
第52批中国博士后基金项目
北京市博士后科研活动经费项目
关键词
莫诺苷
局灶性脑缺血
红细胞压积
大鼠
morroniside
focal cerebral ischemia
hematocrit percentage
rats
