FVLeiden和FIIG20210A与中国人群肺血栓栓塞症的相关性

Association of factor V Leiden and prothrombin G20210A mutation in Chinese patients with pulmonary thromboembolism

目的:探讨凝血因子V基因突变(FVLeiden)和凝血酶原G20210A基因突变(FIIG20210A)与中国人群肺血栓栓塞症的关系。方法:选取45例经过核素肺灌注显像和(或)螺旋CT肺动脉造影(CTPA)确诊的肺血栓栓塞症患者为实验组,85例正常健康人群为对照组。对实验组和对照组分别进行凝血因子V基因突变和凝血酶原G20210A基因突变检测。结果:FVL和凝血酶原G20210A基因杂合子及纯合子突变在PTE患者组及对照组中基因型频率均为0,提示病例组及对照组上述基因型变异频率及突变等位基因频率均为0。结论:凝血因子V基因G1691A突变和凝血因子G20210A基因突变可能与中国人群肺血栓栓塞症无关。

Objective：To study the association of factor V Leiden and prothrombin G20210A mutation in Chinese patients with pulmonary thromboembolism. Methods： Forty five PTE patients and eighty five health controls were recruited. All patients were diag- nosed by lung ventilation/perfusion scan and/or multi-slice CT pulmonary angiography （CTPA）. Results： Factor V Leiden and pro- thrombin G20210A mutation were not found in both PTE patients and controls. Conclusion： Factor V Leiden, prothrombin G20210A mutation may not be associated with PTE risk in Chinese populations.