体质指数对脉搏波传导速度的影响

Effect of body mass index on pulse wave velocity

目的:探讨社区人群中体质指数(body mass index,BMI)与脉搏波传导速度(PWV)的关系。方法:入选南京市鼓楼区40岁以上社区自然人群3 381人,填写调查问卷,收集疾病史、药物治疗史和生活习惯等基本信息,测量身高、体重、腰围、血压,计算BMI,行口服葡萄糖耐量试验(OGTT),测定血脂及PWV。结果:多元逐步线性回归分析显示收缩压(SBP)是PWV的独立危险因素(β=0.478,P<0.001)。协方差分析结果显示校正混杂因素后,PWV和BMI间存在弱的负性相关。代谢健康肥胖者PWV明显低于代谢异常的正常体重者(P<0.01)。结论:BMI不是PWV的独立影响因素,BMI和PWV间的关系很大程度上可以通过BMI和血压的强阳性关系进行解释。

Objective：This study aimed to explore the relationship between body mass index（BMI）and pulse wave velocity（PWV） in the community-dwelling subjects. Methods ：A total of 3381 subjects older than 40 years of age from Gulou district,Nanjing were enrolled. Data of disease history,medication history,habits and etc. were collected by questionnaire. Height,weight,waist circumference and blood pressure were measured. Oral glucose tolerance test （OGTT）was performed. Blood lipid and PWV was assessed. Results：According to the multivariate regression, systolic blood pressure （SBP）was the independent risk factor of PWV （β= 0.478,P 〈 0.001）. A weak and negative association was showed between PWV and BMI after adjustments for confounding factors by covariance analysis. The healthy obesity group had lower PWV than the unhealthy normal weight group （P 〈 0.01 ）. Conclusion： BMI is not independently associated with PWV. The relationship between BMI and PWV is mainly explained by the strong positive association between BMI and BP.