中老年血清维生素D水平与甲状腺自身免疫病

Relationship between serum 25-hydroxy vitamin D and thyroid autoimmunity among middle-aged and elderly individuals

目的:评估中老年人群甲状腺自身免疫与不同程度25羟-维生素D[25(OH)D]缺乏的关系。方法 :研究纳入2 374例中老年人,检测血清25(OH)D及甲状腺自身抗体水平,比较甲状腺抗体阳性组和阴性组间25(OH)D水平及25(OH)D缺乏比例的差异,采用二元Logistic回归分析25(OH)D水平及25(OH)D缺乏对甲状腺自身抗体的影响。结果:女性甲状腺自身抗体阳性比例以及25(OH)D缺乏比例显著高于男性;血清甲状腺过氧化物酶抗体(TPOAb)阳性组25(OH)D水平显著低于血清TPOAb阴性组;甲状腺自身抗体阳性组血清25(OH)D<50 nmol/L的比例显著高于甲状腺自身抗体阴性组;在矫正年龄、性别、体质指数(BMI)、血清FT3和FT4后,血清25(OH)D<50 nmol/L是TPOAb阳性及TPOAb和(或)甲状腺球蛋白抗体(TgAb)阳性的危险因素,OR值分别为1.313和1.287。结论:甲状腺自身抗体阳性人群维生素D缺乏[25(OH)D<50 nmol/L]比例较高,25(OH)D<50 nmol/L是甲状腺自身抗体阳性的危险因素。

Objective：To investigate the relationship between serum 25-hydroxy vitamin D[25（OH）D]deficiency and thyroid autoimmunity among middle-aged and elderly population, nethods：A total of 2374 middle-aged and elderly patients were enrolled in this study. Serum 25 （OH）D and thyroid autoantibody were determined. The levels of 25 （OH）D and the prevalence of 25 （OH）D deficiency were compared between the positive thyroid autoantibody group and the negative thyroid autoantibody group. Binary logistic regression was conducted to investigate the relationship between the levels of 25（OH）D and the prevalence of 25（OH）D deficiency and thyroid autoantibody. Results：Females had higher prevalence of 25 （OH）D deficiency and positive thyroid autoantibody than males. The serum 25 （OH）D level in the positive TPOAb group were significantly lower than those in the negative TPOAb group,and the prevalence of 25 （OH）D deficiency （25 （OH）D〈 50 nmol/L） were significantly higher in the positive thyroid autoantibody group compared with those in the negative thyroid autoantibody group. Binary logistic regression analysis revealed that 25 （OH）D〈 50 nmol/L was a risk factor for positive TPOAb and positive TPOAb and/or TgAb after controlling for age, gender, body mass index （BMI）, serum FT3 and FF4 （OR = 1.313 and OR = 1.287,respectively）. Conclusion：Patients with positive thyroid autoantibody have a high prevalence of 25 （OH）D deficiency, and 25 （OH）D〈 50 nmol/L was a risk factor for positive thyroid autoantibody.