RRLC-Q-TOF-MS法测定安神类中成药、保健食品中14种非法添加的催眠类药物

Study on the analysis of illegally added 14 hypnotic drugs in Chinese traditional patent medicine and healthy foods by RRLC-Q-TOF-MS

目的建立安神类中成药、保健食品中非法添加14种催眠类药物的定性和定量测定方法。方法使用RRLC-Q-TOF-MS作为检测方法，化合物准分子离子峰的保留时间、一级质谱和二级质谱作为定性依据；一级质谱准分子离子峰面积作为定量依据。结果建立安神类中成药、保健食品中非法添加14种催眠类药物的定性和定量检验测定方法，14种成分线性相关系数（r）均〉0．99，回收率80％～120％。结论RRLC-Q-TOF-MS法定性准确，干扰少，定量线性及回收率良好，适用于安神类中成药、保健食品非法添加催眠类药品的定性和定量检验。

Objective To establish a qualitative and quantitative analysis method of illegally added 14 hypnotic drugs in Chinese traditional patent medicine and healthy foods. Methods RRLC-Q-TOF-MS was as the detection method. The qualitative analysis was based on the retention time, ms spectrometer and ms/ms spectrometer. The quantitative analysis was based on the quasi-molecular ion peak areas of lg hypnotic drugs. Results The related coefficients of 14 components were all above 0.99, the recover factors were between 80% ~ 120%. Tile qualitative and quantitative analysis method of illegally added 14 hypnotic drugs in Chinese traditional patent medicine and healthy foods was established. Conclusion This method is accu- rate and less interference, the liner relationships and the recover factors of the quantitative results are all well, which is suitable for the analysis of illegally added 14 hypnotic drugs in Chinese traditional patent medicine and healthy foods.