培哚普利联合氨氯地平治疗原发性高血压合并左心室肥厚的临床疗效观察

The Clinical Efficacy of Perindopril and Amlodipine in the Treatment of Essential Hypertension and Left Ventricular Hypertrophy

目的:观察培哚普利联合氨氯地平治疗原发性高血压合并左心室肥厚的临床疗效。方法:60例原发性高血压合并左心室肥厚患者,按照随机数字表法分为对照组和治疗组,每组30例。治疗组给予培哚普利4 mg/d,氨氯地平5 mg/d,对照组给予氨氯地平5 mg/d,两组疗程32周,观察治疗前后的血压、左室射血分数(LVEF)、左心室重量指数(LVMI)、左心室舒张末期内径(LVDd)、左室舒张末期室间隔厚度(IVS)、心室后壁厚度(PWT)变化。结果:治疗后,两组血压均明显降低,与本组治疗前比较差异均有统计学意义(P<0.05)。治疗后,治疗组收缩压、舒张压、心率均明显低于对照组,两组比较差异均有统计学意义(P<0.05)。治疗组IVS、PWT、LVDd、LVMI明显低于对照组,LVEF明显高于对照组,两组比较差异均有统计学意义(P<0.05)。结论:培哚普利联合氨氯地平治疗原发性高血压合并左心室肥厚患者降压效果显著,有协同降压作用,并能有效逆扭转左心室肥厚。

Objective：To observe the clinical efficacy of perindopril and amlodipine in the treatment of essential hypertension and left ventricular hypertrophy. Method：60 patients with essential hypertension and left ventricular hypertrophy were randomly divided into control group of 30 patients and treatment group of 30 patients. Treatment group was treated with perindopril tablets（4 mg,one time per day）,amlodipine tablets（5 mg,one time per day）,whil control group was treated with amlodipine tablets（5 mg,one time per day）,both groups were treated for 32 weeks. Observed the changes of blood pressure,LVEF, LVMI,LVDd,IVS,PWT in the two groups before and after treatment. Result：The blood pressure of the two groups after treatment were significantly lower than those before treatment（P〈0.05）. The systolic blood pressure,diastolic blood pressure,heart rate of the treatment group was significantly lower than that in control group （P〈0.05）. IVS,PWT,LVDd,LVMI after treatment were significantly lower than those in control group,LVEF was significantly higher than that in control group（P〈0.05）. Conclusion：Perindopril and amlodipine in treatment of essential hypertension and left ventricular hypertrophy can significantly reduce the blood pressure and effectively reverse left ventricular hypertrophy.