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牙龈卟啉菌蛋白酶的研究进展 被引量：4

The research development of porphyromonas gingivalis proteases
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摘要 革兰氏阴性厌氧菌牙龈卟啉菌和牙周炎病因密切相关 ,生物化学和分子生物学的进展表明牙龈卟啉菌可合成多种蛋白酶 ,蛋白酶是细菌重要的毒力因子 ,具有复杂的生理功能。本文简述了牙龈卟啉菌蛋白酶的生物学作用及其在牙周炎组织破坏中的影响。 The gram-negative anaerobic bacterium poryphyromonas gingivalis (Pg) has been strongly associated with the causation of human periodontitis. Recent biochemical and molecular biological approaches have clearly demonstrated that Pg can elaborate proteases which are important in virulence and have complex functions in physiology. This review discusses the biological significance of Pg proteases and summarizes their potential roles of in periodontal destruction. [
作者 张贤华 吴织芬
机构地区 第四军医大学口腔医学院
出处 《牙体牙髓牙周病学杂志》 CAS 2001年第2期129-131,共3页 Chinese Journal of Conservative Dentistry
关键词 蛋白酶 牙龈卟啉菌 牙周炎 proteases porphyromonas gingivalis (Pg) periodontitis
分类号 R780.3 [医药卫生—口腔医学] R781.42 [医药卫生—口腔医学]
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参考文献15

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同被引文献21

  • 1赵守亮,史俊南,肖明振,陈建元.三种根管内厌氧菌荚膜对人牙龈成纤维细胞的生长抑制作用[J].口腔医学纵横,1994,10(4):204-206. 被引量：5
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  • 6Geatch DR, Harris JI, Heasman PA, et al. In vitro studies of lymphocyte apoptosis induced by the periodontal pathogen Porphyromonas gingivalis [ J ]. J Periodontal Res, 1999,34 ( 2 ) :70.
  • 7Gadhavi A,Wilson MO,Tabona P,et al. Inhibition of mitosis and induction of apoptosis in MG63 human osteosarcoma - derived cells in vitro by surface proteins from Actinobacillus actinorncetemcomintans[ J ]. Arch Oral Biol,2000,45 ( 8 ) :707.
  • 8Gurses N, Unlu F, Hekimgil M,et al. Immunohistochemical characterization of lymphocyte subsets in chronic adult periodontitis[J].J Nihon Univ Sch Dent,1996,38(2) :94.
  • 9Afar B, Engel D, Clark EA. Activated lymphocyte subsets in adult periodontitis [ J ]. J Periodontal Res, 1992,27 ( 2 ) : 126.
  • 10Pavloff N, Pemberton PA, Potempa J,et al.Molecular cloning and characterization of Porphyromonas gingivalis lysine-specific gingivain A new member of an emerging family of pathogenic bacterial cysteine proteinases[J].J Biol Chem,1997,272(3):1595

引证文献4

二级引证文献16

牙体牙髓牙周病学杂志
2001年 第2期

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