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胸部开放伤后海水浸泡对实验犬肝功能及形态学的影响 被引量:13

Influence of seawater immersion on liver function and pathological changes after open chest wound in experimental dog
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摘要 目的 :探讨胸部开放伤后海水浸泡对实验犬肝功能及其病理形态学的影响。方法 :实验动物致伤后随机分为对照组 (n=10 )和海水浸泡组 (n=10 )。对照组为单纯胸外伤 ,海水浸泡组的动物于致伤后置入人工配制的海水中。于致伤前及入水 15、30、45分钟以及 1、2、3和 4小时取血测定总胆红素、丙氨酸转氨酶 (AL T)、天冬氨酸转氨酶 (AST)、乳酸脱氢酶 (L DH)和碱性磷酸酶 (AKP) ,同时对肝组织进行光镜及透射电镜检查。结果 :海水浸泡组血液总胆红素、AL T、AST和 L DH明显升高并且出现时间早 ,肝脏有明确的病理形态学改变。而对照组肝功能改变轻微且出现时间晚。结论 Objective:To investigate the influences of seawater immersion on liver function and pathological changes after open chest wound in experimental dog. Methods:Twenty health dogs were divided randomly into two groups. A right open pneumothorax was induced in both groups. Control group( n =10) was chest trauma only but seawater immersion group( n =10) had seawater prepared of artificialness immersion after chest trauma. Blood samples were taken before the injunry and at 15,30,45 minutes as well as 1,2,3,4 hours after injury and water immersion,respectively for both groups.Serum bilirubin, alanine aminotransferase (ALT), aspartate aminotransferase (AST), lactate dehydrogenase (LDH) and alkaline phosphatase (AKP) were assayed. The pathological changes in hepatic tissue were also studied by light microscope and electronic microscope.Results:The serum bilirubin, ALT,AST and LDH were significantly higher and earlier in seawter immersion group than those in control group. Meanwhile the pathological changes in hepatic tissue in seawater immersion group were much more significiant than those in control group.Conclusions:Liver function and its pathological changes appears to be associated with seawater immersion after chest trauma in experimental dog.
出处 《中国危重病急救医学》 CAS CSCD 2001年第4期213-215,共3页 Chinese Critical Care Medicine
基金 全军"九.五"指令性课题! (No.96L 0 0 4)
关键词 海水浸泡 胸部开放伤 肝功能 病理形态学 seawater immersion open chest wound liver function pathological changes
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