肺鳞癌肿瘤微血管密度与临床特征及预后的相关性

The relation between microvascular density and the clinicopathological feature and prognosis of squamous cell lung carcinoma

目的 探讨肿瘤微血管密度 (MVD)与肺鳞癌临床特征及预后的关系。方法 利用免疫组化 ABC法标记肿瘤组织内血管内皮细胞 ,随机观察 2 0个高倍视野下阳性细胞平均数 ,进行各特征间 t检验及相关性分析 ,MVD平均值≥ 5 0为高表达组 ,<5 0为低表达组 ,绘制两组 Kaplan- Meier生存率曲线 ,其生存期差异采用 long-rank检验。结果 MVD与性别无关 (P>0 .0 5 ) ,临床 期显著高于 、 期 (P<0 .0 5 ) , 、 期差异不显著 (P>0 .0 5 ) ;T3显著高于 T1 、T2 (P<0 .0 5 ) ,T1 、T2 差异不显著 (P>0 .0 5 ) ;中低分化者显著高于高分化者 (P<0 .0 5 ) ;MVD、N分期与生存期相关性较密切 (分别 r=- 0 .6 37,P<0 .0 0 1;r=- 0 .5 12 ,P<0 .0 0 1) ,MVD与生存期相关性最密切。结论 MVD、N分期、病理分级、临床分期与肺鳞癌患者的预后呈负相关 ,MVD、N分期相关性较显著 ,MVD可作为肺鳞癌评价预后。

Objective To study the relation between microvascular density and the feature and prognosis in patients with squamous cell lung carcinoma.Methods Immunohistochemical ABC method was used to detect the microvascular denisty (MVD).The difference of MVD was determined by t test and linear correlation analysis,survial rates were described by Kaplan meier cures,long rank test was used to compare the difference.Results MVD was statistically higher in clinic stage Ⅲ and pathological grade Ⅲ than stage Ⅰ and Ⅱ or pathological Ⅰ and Ⅱ,respectively.But it had no statistical difference between stage Ⅰ and Ⅱ or pathological Ⅰ and Ⅱ.MVD had very strong statistical difference between N 0 and N 1～3 .MVD was closely correlated with survival time.Conclusion MVD can be used as a marker of prognosis in patients with squamous cell lung cancer.\;