3-甲胺基-1,2-丙二醇的合成

Synthesis of 3-Methylamino-1,2-propandiol

叙述了非离子造影剂碘普罗胺重要原料 3 -甲胺基 - 1 ,2 -丙二醇的合成 ,以环氧氯丙烷为起始原料 ,经水解、氨化得产物 ,二步反应总收率为 41 .3 % ;实验表明 ,当反应温度为 80℃、甲胺 /3 -氯- 1 ,2 -丙二醇摩尔比为 4.5时 ,3 -甲胺基 - 1 ,2 -丙二醇收率最高 ,为 5 6 .3 %。

Methylamino-1,2-propandiol is an important raw material of Iopromide. Its synthesis was from epichlorohydrin by hydrolysis and ammoniaiton. The overall yield was 41.3%. The results showed the best yield was 56.3% when the reaction temperature was 80℃ and the molar ratio of methylamine /3-chloro-1,2-propandiol was 4.5.