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肝豆片Ⅰ号对肝豆状核变性患者神经电生理的影响 被引量:6

Effect of Gandou Tablet I on Neurological Electrophysiology in Patients of Hepatolenticular Degeneration
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摘要 目的 :观察中药肝豆片Ⅰ号对肝豆状核变性 (HLD)患者神经电生理的影响。方法 :32例HLD患者治疗前检测脑电图 (VEEG)、肌电图 (EMG)及脑干听觉诱发电位 (BAEP) ,于口服肝豆片Ⅰ号治疗4周后 ,对治疗前有异常神经电生理改变的患者进行复查。结果 :HLD患者治疗后在临床症状明显改善的同时 ,VEEG、EMG及BAEP的有效率依次为 71 4 3% (5 /7例 )、70 0 0 % (7/10例 )、6 6 6 7% (2 0 /30例 ) ,其有效率差异无显著性 (P >0 0 5 )。HLD患者治疗前Ⅲ、Ⅴ波潜伏期 (PL)及Ⅰ Ⅲ、Ⅲ Ⅴ、Ⅰ Ⅴ波峰间期(IPL)均较健康对照组延长 (P <0 0 5 ,P <0 0 1) ;治疗后Ⅲ Ⅴ、Ⅰ Ⅴ波IPL均有改善。结论 :神经电生理检查对HLD有辅助诊断及疗效判断价值 ,肝豆片Ⅰ号能改善HLD患者异常的神经电生理。 To observe the influence of Gandou Tablet I (GD I) on neurologic electrophysiology in patients of hepatolenticular degeneration (HLD). Methods: Vigilance controlled electroencephalogram (VEEG), electromyogram (EMG) and brain stem auditory evoked potential (BAEP) in 32 cases of HLD were examined before GD I treatment, and reexamined after 4 weeks of treatment in those with abnormal neurologic electrophysiology. Results: At the same time of clinical symptom improvement after treatment, the abnormal VEEG, EMG and BAEP also improved with the effective rate of 71.43%, 70% and 66.67% respectively, their constitutional ratio were different insignificantly, P>0 05. The peak latency (PL) of Ⅲ, Ⅴ waves and interpeak latency (IPL) of Ⅰ Ⅲ, Ⅲ Ⅴ and Ⅰ Ⅴ waves in patients before treatment were all greatly prolonged, compared with those in the healthy control group (P<0 05 or 0.01), the IPL of Ⅲ Ⅴ and Ⅰ Ⅴ waves were markedly improved after treatment. Conclusion: Neurologic electrophysiologic examination was valuable for complementary diagnosis and therapeutic effect evaluation to HLD. GD I could improve the abnormal neurologic electrophysiologic parameters.
出处 《中国中西医结合杂志》 CAS CSCD 北大核心 2002年第1期14-17,共4页 Chinese Journal of Integrated Traditional and Western Medicine
基金 国家自然科学基金资助课题 (No .39570 878)
关键词 肝豆状核变性 肝豆片I号 脑电图 肌电图 脑干听觉诱发电位 中药 hepatolenticular degeneration, Gandou Tablet I, electroencephalogram, electromyogram, brain stem auditory evoked potential
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