当归补血汤对心肌缺血再灌注损伤大鼠心功能的作用

Effects of Angelicae Sinensis Decoction for Supplementing Blood on the cardiac function in myocardial ischemia reperfusion injury of rats

在结扎大鼠冠状动脉左室前降支３０ ｍｉｎ 再灌注１２０ｍｉｎ 造成心肌缺血再灌注损伤模型，当归补血汤能够对抗左心室内压（ＬＶＳＰ） 、左心室内压最大上升与下降速率（ ±ｄｐ／ｄｔｍａｘ） 、动脉血压的下降，并能够使心肌组织Ｎａ＋Ｋ＋ＡＴＰ 酶活性及丙二醛（ ＭＤＡ） 含量降低和ｃＡＭＰ 的含量增高。提示当归补血汤对大鼠心肌缺血再灌注引起的心功能减弱具有明显的保护作用。

Effects of Angelicae Sinensis Decoction for Supplementing Blood (ASDSB) on the cardiac function in myocardial ischemia reperfusion injury were studied by the left anterior descending coronary artery occlusion in 30 min and reperfusion in 120 min from the opening chest rats.The findings showed that ASDSB attenuated declines of the amplitudes of LVSP and ±dp/dt max and arterial pressure in rat heart injured by ischemia reperfusion in vivo , it decreased Na + K + ATPase activity and level of malondialdehyde(MDA) production and increased cAMP content in the ischemic myocardium.The results suggest that the effects of ASDSB alleviating injury on cardiac function in the process of ischemia reperfusion may be related to the mechanism of inproving energy metabolism, scavarging the oxygen free radicals and inhibiting production of free radicals in the ischemic myocardium.